{"id":72684,"date":"2024-11-04T11:00:00","date_gmt":"2024-11-04T10:00:35","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/zaostrene-na-nobelove-ceny\/zaostrene-na-nobelove-ceny-2023-2\/"},"modified":"2024-12-05T14:48:50","modified_gmt":"2024-12-05T13:48:50","slug":"zaostrene-na-nobelove-ceny-2024","status":"publish","type":"page","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/zaostrene-na-nobelove-ceny\/zaostrene-na-nobelove-ceny-2024\/","title":{"rendered":"ZAOSTREN\u00c9 na Nobelove ceny 2024"},"content":{"rendered":"<style>.kb-image72684_c1626a-37 .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kb-image72684_c1626a-37 img.kb-img, .kb-image72684_c1626a-37 .kb-img img{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image72684_c1626a-37 size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1170\" height=\"200\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2023\/11\/banner-il-Nobelove-Ceny-archiv.png\" alt=\"\" class=\"kb-img wp-image-63104\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2023\/11\/banner-il-Nobelove-Ceny-archiv.png 1170w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2023\/11\/banner-il-Nobelove-Ceny-archiv-300x51.png 300w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2023\/11\/banner-il-Nobelove-Ceny-archiv-1024x175.png 1024w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2023\/11\/banner-il-Nobelove-Ceny-archiv-768x131.png 768w\" sizes=\"auto, (max-width: 1170px) 100vw, 1170px\" \/><\/figure>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{display:flex;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:0px;padding-left:var(--global-kb-spacing-xxs, 0.5rem);}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col,.kadence-column72684_c463f7-e7 > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col > .aligncenter{width:100%;}.kt-row-column-wrap > .kadence-column72684_c463f7-e7{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column72684_c463f7-e7{position:relative;}@media all and (max-width: 1024px){.kt-row-column-wrap > .kadence-column72684_c463f7-e7{align-self:center;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7{align-self:auto;}}@media all and (max-width: 1024px){.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 1024px){.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kt-row-column-wrap > .kadence-column72684_c463f7-e7{align-self:center;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7{align-self:auto;}.kt-inner-column-height-full:not(.kt-has-1-columns) > .wp-block-kadence-column.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}.kadence-column72684_c463f7-e7 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column72684_c463f7-e7\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-center\">Vedenie fakulty poz\u00fdva \u0161tudentov, u\u010dite\u013eov ale aj absolventov a&nbsp;\u0161irok\u00fa verejnos\u0165 na <strong>stretnutie<\/strong> <strong>s&nbsp;vedcami Pr\u00edrodovedeckej fakulty UPJ\u0160 v Ko\u0161iciach,<\/strong> ktor\u00ed&nbsp; pribl\u00ed\u017eia problematiku v\u00fdskumu, za ktor\u00fd boli udelen\u00e9 Nobelove ceny 2024 v&nbsp;kateg\u00f3ri\u00e1ch <strong><em>Fyzika, Ch\u00e9mia, Fyziol\u00f3gia\/Medic\u00edna.<\/em><\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center\"><strong>5. december 2024, 16.30 h \u2013 verejnos\u0165, \u0161tudenti, u\u010ditelia<\/strong><br>Historick\u00e1 aula UPJ\u0160, \u0160rob\u00e1rova 2, Ko\u0161ice<br>vstup vo\u013en\u00fd<\/p>\n\n\n\n<p class=\"has-text-align-center has-text-align-justify\"><s><strong>6. december 2024, 9.00 h <\/strong> <strong>\u2013 \u017eiaci a u\u010ditelia S\u0160<\/strong><\/s> <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-lekarska-f-color\"><strong>&#8211; PODUJATIE ZRU\u0160EN\u00c9,  N\u00c1HRADN\u00dd TERM\u00cdN: JANU\u00c1R 2025<\/strong><\/mark><br>aula prof. Prasli\u010dku (RB0A5), \u0160rob\u00e1rova 2, Ko\u0161ice<br>registr\u00e1cia \u00fa\u010dasti: <a class=\"ek-link\" href=\"mailto:pf-ovv@upjs.sk\">pf-ovv@upjs.sk<\/a><br>term\u00edn: <strong>do 29.11.2024<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-prirodovedecka-f-color has-text-color\"><strong>Nobelova cena za fyziku 20<\/strong>24<\/h4>\n\n\n<style>.kadence-column72684_321171-36 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-right:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-xxs, 0.5rem);padding-left:var(--global-kb-spacing-xxs, 0.5rem);}.kadence-column72684_321171-36 > .kt-inside-inner-col,.kadence-column72684_321171-36 > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column72684_321171-36 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column72684_321171-36 > .kt-inside-inner-col{flex-direction:column;}.kadence-column72684_321171-36 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column72684_321171-36 > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column72684_321171-36 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column72684_321171-36{position:relative;}@media all and (max-width: 1024px){.kadence-column72684_321171-36 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column72684_321171-36 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column72684_321171-36\"><div class=\"kt-inside-inner-col\">\n<p><strong>Ako sa umel\u00e9 neur\u00f3nov\u00e9 siete u\u010dia a&nbsp;dok\u00e1\u017eu rozm\u00fd\u0161\u013ea\u0165?<\/strong><\/p>\n\n\n\n<p>Predn\u00e1\u0161aj\u00faci: <strong><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/gabriela.andrejkova\/\">doc. RNDr. Gabriela Andrejkov\u00e1, CSc.<\/a><\/strong>, <a href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/uinf\/\">\u00dastav informatiky<\/a>, PF UPJ\u0160 v&nbsp;Ko\u0161iciach<\/p>\n\n\n\n<p class=\"has-text-align-justify\"><strong>Anot\u00e1cia:<\/strong> Dvaja v\u00fdznamn\u00ed vedci \u2013 <strong>John Hopfield<\/strong> z Princetone University a <strong>Geoffrey Hinton<\/strong> z&nbsp;Toronto University \u2013 z\u00edskali Nobelovu cenu za fyziku (2024). Ich vedeck\u00e9 objavy s\u00fa na rozhran\u00ed viacer\u00fdch vedeck\u00fdch discipl\u00edn a&nbsp;viedli k&nbsp;rozvoju s\u00fa\u010dasnej modernej umelej inteligencie.&nbsp; <strong>Hlavn\u00fd pr\u00ednos J. Hopfielda <\/strong>\u2013 fyzika a neurovedca \u2013 je v oblasti autoasociat\u00edvnych pam\u00e4\u0165ov\u00fdch modelov (hlavne 80. roky 20. storo\u010dia), ale jeho in\u0161pirat\u00edvna pr\u00e1ca zaznamenala v posledn\u00fdch rokoch o\u017eivenie v podobe vylep\u0161en\u00fdch modelov. G. Hinton \u2013 po\u010d\u00edta\u010dov\u00fd vedec a kognit\u00edvny psychol\u00f3g \u2013 bol v posledn\u00fdch desa\u0165ro\u010diach (od 70. rokov 20. storo\u010dia) pravideln\u00fdm v\u00fdznamn\u00fdm prispievate\u013eom k algoritmom u\u010denia pre neur\u00f3nov\u00e9 siete. Je tie\u017e spoluautorom back-propagation tr\u00e9novacieho algoritmu pre rekurentn\u00e9 neur\u00f3nov\u00e9 siete.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">V&nbsp;predn\u00e1\u0161ke vysvetl\u00edme modely neur\u00f3nov\u00fdch siet\u00ed a&nbsp;princ\u00edpy (objavy), ktor\u00e9 viedli k&nbsp;ich vytvoreniu, a&nbsp;ktor\u00fdch autormi s\u00fa pr\u00e1ve J. Hopfield a&nbsp;G. Hinton. Tieto modely s\u00fa z\u00e1kladn\u00fdmi modelmi strojov\u00e9ho u\u010denia a&nbsp;hlavne Boltzmannov model prispieva k hlbok\u00e9mu u\u010deniu, ktor\u00e9 je d\u00f4le\u017eit\u00e9 vo ve\u013ek\u00fdch neur\u00f3nov\u00fdch sie\u0165ach pou\u017e\u00edvan\u00fdch v&nbsp;mnoh\u00fdch praktick\u00fdch aplik\u00e1ci\u00e1ch.&nbsp;<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-prirodovedecka-f-color has-text-color\"><strong>Nobelova cena za ch\u00e9miu 20<\/strong>24<\/h4>\n\n\n<style>.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-right:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-xxs, 0.5rem);padding-left:var(--global-kb-spacing-xxs, 0.5rem);}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col,.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{flex-direction:column;}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column72684_cd3d2f-c7{position:relative;}@media all and (max-width: 1024px){.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column72684_cd3d2f-c7 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column72684_cd3d2f-c7\"><div class=\"kt-inside-inner-col\">\n<p><strong><br><br>Ako umel\u00e1 inteligencia zmenila sk\u00famanie \u0161trukt\u00fary prote\u00ednov<\/strong><\/p>\n\n\n\n<p>Predn\u00e1\u0161aj\u00faci: <strong><a href=\"https:\/\/www.upjs.sk\/UPJS\/zamestnanec\/michal.nemergut\/\">RNDr. Michal Nemergut, PhD.<\/a><\/strong>, <a href=\"https:\/\/cib-center.org\/\">Centrum Interdisciplin\u00e1rnych Biovied<\/a> <a href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/\">TIP-UPJ\u0160<\/a><\/p>\n\n\n\n<p class=\"has-text-align-justify\"><strong>Anot\u00e1cia:<\/strong> Nobelovu cenu za ch\u00e9miu za rok 2024 z\u00edskali <strong>David Baker<\/strong>, <strong>Demis Hassabis<\/strong> a <strong>John Jumper<\/strong> za prelomov\u00e9 objavy v oblasti dizajnu prote\u00ednov a predikcie ich \u0161trukt\u00fary. Bakerovi bola cena udelen\u00e1 za jeho pr\u00e1cu v oblasti v\u00fdvoja prote\u00ednov na mieru, pri\u010dom jeho v\u00fdskum vyu\u017e\u00edva po\u010d\u00edta\u010dov\u00e9 modelovanie na vytv\u00e1ranie prote\u00ednov s nov\u00fdmi funkciami, ako je napr\u00edklad rozpozn\u00e1vanie jedovat\u00fdch l\u00e1tok alebo blokovanie v\u00edrusov. Tento pr\u00edstup, zalo\u017een\u00fd na programe <strong>Rosetta<\/strong>, otv\u00e1ra nov\u00e9 mo\u017enosti pre dizajn prote\u00ednov pre biomedic\u00ednske a environment\u00e1lne aplik\u00e1cie. Druh\u00e1 polovica ocenenia patr\u00ed <strong>Hassabisovi<\/strong> a <strong>Jumperovi<\/strong> za v\u00fdvoj umelej inteligencie <strong>AlphaFold<\/strong>, ktor\u00e1 predpoved\u00e1 priestorov\u00e9 usporiadanie prote\u00ednov s vysokou presnos\u0165ou. T\u00e1to technol\u00f3gia umo\u017e\u0148uje vedcom efekt\u00edvne ur\u010dova\u0165 3D \u0161trukt\u00faru prote\u00ednov na z\u00e1klade sekvencie aminokysel\u00edn, \u010do je k\u013e\u00fa\u010dov\u00e9 pre pochopenie ich biologickej funkcie. Udelenie tejto Nobelovej ceny tak poukazuje na z\u00e1sadn\u00fd pr\u00ednos umelej inteligencie v&nbsp;\u0161trukt\u00farnej biol\u00f3gii.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-prirodovedecka-f-color has-text-color\"><strong>Nobelova cena za fyziol\u00f3giu\/medic\u00ednu 20<\/strong>24<\/h4>\n\n\n<style>.kadence-column72684_dc1228-4f > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xxs, 0.5rem);padding-right:var(--global-kb-spacing-xxs, 0.5rem);padding-bottom:var(--global-kb-spacing-xxs, 0.5rem);padding-left:var(--global-kb-spacing-xxs, 0.5rem);}.kadence-column72684_dc1228-4f > .kt-inside-inner-col,.kadence-column72684_dc1228-4f > .kt-inside-inner-col:before{border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;}.kadence-column72684_dc1228-4f > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column72684_dc1228-4f > .kt-inside-inner-col{flex-direction:column;}.kadence-column72684_dc1228-4f > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column72684_dc1228-4f > .kt-inside-inner-col{background-color:#F4F4F4;}.kadence-column72684_dc1228-4f > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column72684_dc1228-4f{position:relative;}@media all and (max-width: 1024px){.kadence-column72684_dc1228-4f > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column72684_dc1228-4f > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column72684_dc1228-4f\"><div class=\"kt-inside-inner-col\">\n<p><strong>mikroRNA \u2013 mali\u010dk\u00e9 molekuly s ve\u013ek\u00fdm vplyvom na aktivitu g\u00e9nov<\/strong><\/p>\n\n\n\n<p>Predn\u00e1\u0161aj\u00faci: <strong><a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.jendzelovska\/\">RNDr. Zuzana Jend\u017eelovsk\u00e1, PhD<\/a><\/strong>., Katedra bunkovej biol\u00f3gie, <a href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/pracoviska\/ustavy-pf\/ubev\/\">\u00dastav biologick\u00fdch a&nbsp;ekologick\u00fdch vied<\/a> PF UPJ\u0160 v&nbsp;Ko\u0161iciach<\/p>\n\n\n\n<p class=\"has-text-align-justify\"><strong>Anot\u00e1cia:<\/strong> Jedn\u00fdm z&nbsp;najprekvapivej\u0161\u00edch zisten\u00ed v&nbsp;oblasti genetiky a&nbsp;molekul\u00e1rnej biol\u00f3gie je, ako m\u00e1lo g\u00e9nov k\u00f3duj\u00facich prote\u00edny sa nach\u00e1dza v&nbsp;gen\u00f3me organizmov. \u013dudsk\u00fd gen\u00f3m obsahuje iba pribli\u017ene 20&nbsp;000 g\u00e9nov, pri\u010dom p\u00f4vodn\u00fd odhad bol okolo 100&nbsp;000. Ako teda dok\u00e1\u017ee tak\u00e9 mal\u00e9 mno\u017estvo g\u00e9nov podmieni\u0165 variabilitu a&nbsp;rozmanitos\u0165 medzi jednotlivcami, ale aj medzi bunkami v&nbsp;r\u00e1mci jedn\u00e9ho organizmu? Vysvetlen\u00edm je komplexnos\u0165 a&nbsp;mno\u017estvo mechanizmov zodpovedn\u00fdch za regul\u00e1ciu g\u00e9novej aktivity a&nbsp;expresie. Dnes je u\u017e zn\u00e1me, \u017ee aktivita g\u00e9nov je kontrolovan\u00e1 na viacer\u00fdch \u00farovniach, a&nbsp;to nie len v&nbsp;jadre bunky, ale aj v&nbsp;cytoplazme. Tieto regula\u010dn\u00e9 mechanizmy kontroluj\u00fa, ktor\u00e9 g\u00e9ny a&nbsp;v&nbsp;akej miere bud\u00fa \u201eprepisovan\u00e9\u201c a \u201eprekladan\u00e9\u201c do podoby prote\u00ednu. K&nbsp;poznaniu, \u017ee cytoplazmatick\u00e1 \u00farove\u0148 regul\u00e1cie g\u00e9nov je rovnako d\u00f4le\u017eit\u00e1 ako t\u00e1 jadrov\u00e1, prispeli aj <strong>aktu\u00e1lni nositelia <u>Nobelovej ceny za fyziol\u00f3giu a&nbsp;medic\u00ednu<\/u>, Victor Ambros a&nbsp;Gary Ruvkun<\/strong>. T\u00edto dvaja americk\u00ed vedci <strong>objavili prv\u00fa mikroRNA (miRNA)<\/strong> v&nbsp;modelovom organizme h\u00e1\u010fatko oby\u010dajn\u00e9 (<em>Caenorhabditis elegans<\/em>) a&nbsp;<strong>pop\u00edsali, ako funguje mechanizmus sti\u0161ovania g\u00e9nov v&nbsp;cytoplazme bunky pomocou t\u00fdchto mal\u00fdch regula\u010dn\u00fdch molek\u00fal<\/strong>. Ak\u00fd je v\u00fdznam miRNA v&nbsp;kontrole aktivity g\u00e9nov a&nbsp;ich \u00faloha vo fyziologick\u00fdch, ale aj patologick\u00fdch procesoch prebiehaj\u00facich na \u00farovni bunky a&nbsp;cel\u00e9ho organizmu, v\u00e1m radi pribl\u00ed\u017eime v&nbsp;pripravovanej predn\u00e1\u0161ke.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong><a href=\"https:\/\/www.nobelprize.org\/all-nobel-prizes-2024\/\" target=\"_blank\" rel=\"noreferrer noopener\">Viac inform\u00e1ci\u00ed o udelen\u00ed Nobelov\u00fdch cien 2024<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column72684_fbce59-4d > .kt-inside-inner-col,.kadence-column72684_fbce59-4d > 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