{"id":16518,"date":"2020-06-18T11:45:44","date_gmt":"2020-06-18T11:45:44","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/"},"modified":"2022-09-28T12:17:11","modified_gmt":"2022-09-28T12:17:11","slug":"23269","status":"publish","type":"cpt_aktualne_spravy","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/","title":{"rendered":"Z\u00e1hadn\u00e1 skupina cerobrospin\u00e1lny mok-kontaktuj\u00facich neur\u00f3nov je pravdepodobne e\u0161te z\u00e1hadnej\u0161ia"},"content":{"rendered":"<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\">V\u00fdskumn\u00e1 skupina z\u00a0<strong style=\"color:rgb(0, 0, 0); font-family:calibri,sans-serif; font-size:14.6667px\"><a href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/ustav\/ubev\/\" target=\"_blank\" rel=\"noopener\">\u00dastavu biologick\u00fdch a\u00a0ekologick\u00fdch vied PF UPJ\u0160 v\u00a0Ko\u0161iciach<\/a><\/strong>, veden\u00e1 <a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.daxnerova\/\" style=\"font-family: calibri, sans-serif; font-size: 14.6667px;\" target=\"_blank\" rel=\"noopener\"><em>Doc. RNDr. Zuzanou Daxnerovou, CSc.<\/em><\/a> v\u00a0spolupr\u00e1ci s\u00a0t\u00edmom <em>Laboratories of Pharmacology Univerzity v\u00a0Mil\u00e1ne<\/em> publikovala v\u00a0prest\u00ed\u017enom neurobiologickom \u010dasopise <strong>The Journal of Comparative Neurology<\/strong> v\u00fdsledky experimentov zaoberaj\u00facich sa neur\u00f3nmi kontaktuj\u00facimi cerebrospin\u00e1lny mok v\u00a0mieche hlodavcov.<\/p>\n<p style=\"text-align: justify;\"><strong>Cerebrospin\u00e1lny mok-kontaktuj\u00face neur\u00f3ny<\/strong> predstavuj\u00fa starobyl\u00fa skupinu neur\u00f3nov, ktor\u00e9 sa nach\u00e1dzaj\u00fa v\u00a0stene mozgov\u00fdch kom\u00f4r a\u00a0centr\u00e1lneho kan\u00e1la miechy. Od ich objavu v\u00a0rokoch 1920, resp. 1921 uplynulo storo\u010die, po\u010das ktor\u00e9ho postupne prib\u00fadali inform\u00e1cie o distrib\u00facii a\u00a0morfol\u00f3gii t\u00fdchto neur\u00f3nov u\u00a0r\u00f4znych \u017eivo\u010d\u00ed\u0161nych druhov. V\u00a0porovnan\u00ed s\u00a0in\u00fdmi skupinami neur\u00f3nov ost\u00e1va ich funkcia dodnes zahalen\u00e1 r\u00fa\u0161kom tajomstva. V\u00fdsledky z\u00edskan\u00e9 u\u00a0ni\u017e\u0161\u00edch skup\u00edn stavovcov (mihule, ryby, mloky, plazy) indikuj\u00fa zapojenie t\u00fdchto neur\u00f3nov do monitorovania pr\u00fadenia a\u00a0zlo\u017eenia cerebrospin\u00e1lneho moku, \u00fa\u010dasti na motorike, \u010di dokonca pri regenerovan\u00ed po\u0161kodenej miechy. Tieto inform\u00e1cie navodzuj\u00fa dojem, \u017ee ide o\u00a0d\u00f4le\u017eit\u00fa skupinu neur\u00f3nov so s\u013eubn\u00fdm potenci\u00e1lom. Na rozdiel od ni\u017e\u0161\u00edch stavovcov je nervov\u00fd syst\u00e9m cicavcov, ku ktor\u00fdm patr\u00ed aj \u010dlovek, podstatne komplexnej\u0161\u00ed \u010do na jednej strane komplikuje jeho v\u00fdskum a\u00a0na druhej strane vytv\u00e1ra dopyt po u\u017eito\u010dn\u00fdch inform\u00e1ci\u00e1ch, ktor\u00e9 by sa mohli premietnu\u0165 do biomedic\u00ednskych aplik\u00e1ci\u00ed a\u00a0nov\u00fdch terapeutick\u00fdch strat\u00e9gi\u00ed. V\u00a0tomto oh\u013eade <strong>prin\u00e1\u0161a najnov\u0161\u00ed v\u00fdskum experiment\u00e1lnej skupiny z\u00a0\u00dastavu biologick\u00fdch a\u00a0ekologick\u00fdch vied skeptickej\u0161\u00ed poh\u013ead na d\u00f4le\u017eitos\u0165 t\u00fdchto neur\u00f3nov v\u00a0mieche cicavcov.\u00a0<\/strong><\/p>\n<p style=\"text-align: center;\"><strong><img decoding=\"async\" alt=\"\" src=\"http:\/\/www.upjs.sk\/\/app\/uploads\/sites\/10\/2022\/09\/Sevcobr1zmensena.jpg\" style=\"width:70%\" \/><\/strong><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size:12px\"><em><strong>Na obr\u00e1zku z konfok\u00e1lneho mikroskopu<\/strong> je zachyten\u00e1 \u010das\u0165 miechy laborat\u00f3rnej my\u0161i okolo centr\u00e1lneho kan\u00e1la (sch\u00e9matick\u00fd obr\u00e1zok celkom na\u013eavo). Pre t\u00fato oblas\u0165 je typick\u00e9, \u017ee v stene centr\u00e1lneho kan\u00e1la (vyzna\u010den\u00e9 \u017eltou preru\u0161ovanou \u010diarou) sa nach\u00e1dzaj\u00fa cerebrospin\u00e1lny mok-kontaktuj\u00face neur\u00f3ny (vyzna\u010den\u00e9 zelenou). \u010cerven\u00e1 farba zn\u00e1zor\u0148uje prote\u00edn typick\u00fd pre neur\u00f3ny (potvrdenie neuron\u00e1lneho p\u00f4vodu t\u00fdchto buniek), siv\u00e1 zn\u00e1zor\u0148uje bunkov\u00e9 jadr\u00e1.<\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; color:black; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\">Vedeck\u00fd t\u00edm z\u00a0\u00dastavu biologick\u00fdch a\u00a0ekologick\u00fdch vied PF UPJ\u0160<\/span><\/strong><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; color:black; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\"> v\u00a0spolupr\u00e1ci s\u00a0kolegami z\u00a0Mil\u00e1nskej Univerzity<strong> ako prv\u00ed dok\u00e1zali, \u017ee tieto neur\u00f3ny sa m\u00f4\u017eu nach\u00e1dza\u0165 aj \u00faplne mimo svojho prirodzen\u00e9ho &#8222;terit\u00f3ria&#8220; v takzvanej ektopickej poz\u00edcii. <\/strong>Taktie\u017e zistili, \u017ee u kme\u0148a my\u0161\u00ed C57Bl\/6N, ktor\u00fd je pomerne be\u017ene vyu\u017e\u00edvan\u00fd v\u00a0biomedic\u00ednskom v\u00fdskume, sa dokonca takmer v\u0161etky cerebrospin\u00e1lny mok-kontaktuj\u00face neur\u00f3ny nach\u00e1dzaj\u00fa v\u00a0ektopickej poz\u00edcii a\u00a0identifikovali g\u00e9ny, ktor\u00fdch mut\u00e1cie m\u00f4\u017eu za ich netypick\u00fa polohu a\u00a0morfol\u00f3giu.<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; color:black; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\"><img decoding=\"async\" alt=\"\" src=\"http:\/\/www.upjs.sk\/\/app\/uploads\/sites\/10\/2022\/09\/Sevcobr2zmensena.jpg\" style=\"width:60%\" \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size:12px\"><em><strong>Mikrofotografie <\/strong>zn\u00e1zor\u0148uj\u00face usporiadanie cerebrospin\u00e1lny mok-kontaktuj\u00facich neur\u00f3nov u\u00a0stavovcov (v\u013eavo), pri\u010dom doteraz bolo presk\u00faman\u00fdch vy\u0161e 200 \u017eivo\u010d\u00ed\u0161nych druhov a\u00a0u\u00a0my\u0161\u00ed kme\u0148a C57Bl\/6N (vpravo).<\/em><\/span><\/p>\n<p style=\"text-align: justify;\">Ektopick\u00e1 poz\u00edcia a\u00a0pozmenen\u00fd tvar t\u00fdchto neur\u00f3nov indikuj\u00fa, \u017ee svoju funkciu tieto neur\u00f3ny zrejme nem\u00f4\u017eu vykon\u00e1va\u0165 \u201erovnako dobre\u201c, ako je tomu u\u00a0in\u00fdch \u017eivo\u010d\u00ed\u0161nych druhov. Napriek tomu nie je zn\u00e1me, \u017ee by my\u0161i kme\u0148a C57Bl\/6N trpeli evidentn\u00fdm neurologick\u00fdm deficitom. <strong>\u010ci s\u00fa skuto\u010dne tieto bunky v\u00a0mieche cicavcov iba evolu\u010dn\u00fdm pozostatkom, alebo maj\u00fa svoju funkciu ost\u00e1va nateraz z\u00e1hadou.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Odkaz na publikovan\u00fa \u0161t\u00fadiu:<\/strong><\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/doi.org\/10.1002\/cne.24909\" target=\"_blank\" rel=\"noopener\">Tonelli Gombalov\u00e1 Z, Ko\u0161uth J, Alexovi\u010d Matia\u0161ov\u00e1 A, et al. Majority of cerebrospinal fluidcontacting neurons in the spinal cord of C57Bl\/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. J Comp Neurol. 2020;1\u201328.<\/a>\u00a0<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p style=\"text-align: justify;\"><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; color:black; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\">V\u00fdskumn\u00e1 skupina z\u00a0<strong><a href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/ustav\/ubev\/\" target=\"_blank\" rel=\"noopener\">\u00dastavu biologick\u00fdch a\u00a0ekologick\u00fdch vied PF UPJ\u0160 v\u00a0Ko\u0161iciach<\/a> <\/strong>, veden\u00e1 <a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.daxnerova\/\" target=\"_blank\" rel=\"noopener\"><em>Doc. RNDr. Zuzanou Daxnerovou, CSc.<\/em><\/a> v\u00a0spolupr\u00e1ci s\u00a0t\u00edmom <em>Laboratories of Pharmacology Univerzity v\u00a0Mil\u00e1ne<\/em> publikovala v\u00a0prest\u00ed\u017enom neurobiologickom \u010dasopise <\/span><span style=\"color:#A52A2A\"><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\"><strong>The Journal of Comparative Neurology<\/strong><\/span><\/span><span style=\"background-attachment:initial; background-clip:initial; background-image:initial; background-origin:initial; background-position:initial; background-repeat:initial; background-size:initial; color:black; font-family:calibri,sans-serif; font-size:11pt; line-height:107%\"> v\u00fdsledky experimentov zaoberaj\u00facich sa neur\u00f3nmi kontaktuj\u00facimi cerebrospin\u00e1lny mok v\u00a0mieche hlodavcov<\/span><\/p>\n","protected":false},"author":1,"featured_media":16521,"menu_order":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}"},"categories":[],"tags":[],"tax_aktuality":[],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Z\u00e1hadn\u00e1 skupina cerobrospin\u00e1lny mok-kontaktuj\u00facich neur\u00f3nov je pravdepodobne e\u0161te z\u00e1hadnej\u0161ia - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Z\u00e1hadn\u00e1 skupina cerobrospin\u00e1lny mok-kontaktuj\u00facich neur\u00f3nov je pravdepodobne e\u0161te z\u00e1hadnej\u0161ia - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"V\u00fdskumn\u00e1 skupina z\u00a0\u00dastavu biologick\u00fdch a\u00a0ekologick\u00fdch vied PF UPJ\u0160 v\u00a0Ko\u0161iciach , veden\u00e1 Doc. RNDr. Zuzanou Daxnerovou, CSc. v\u00a0spolupr\u00e1ci s\u00a0t\u00edmom Laboratories of Pharmacology Univerzity v\u00a0Mil\u00e1ne publikovala v\u00a0prest\u00ed\u017enom neurobiologickom \u010dasopise The Journal of Comparative Neurology v\u00fdsledky experimentov zaoberaj\u00facich sa neur\u00f3nmi kontaktuj\u00facimi cerebrospin\u00e1lny mok v\u00a0mieche hlodavcov\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/\" \/>\n<meta property=\"og:site_name\" content=\"Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-28T12:17:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2022\/09\/DSC03855zmensena.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"664\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Predpokladan\u00fd \u010das \u010d\u00edtania\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 min\u00faty\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/\",\"url\":\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/23269\/\",\"name\":\"Z\u00e1hadn\u00e1 skupina cerobrospin\u00e1lny mok-kontaktuj\u00facich neur\u00f3nov je pravdepodobne e\u0161te z\u00e1hadnej\u0161ia - 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