{"id":16428,"date":"2021-04-26T16:30:40","date_gmt":"2021-04-26T16:30:40","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/"},"modified":"2022-09-28T12:16:33","modified_gmt":"2022-09-28T12:16:33","slug":"24773","status":"publish","type":"cpt_aktualne_spravy","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/","title":{"rendered":"Nov\u00e9 zl\u00fa\u010deniny striebra proti bakt\u00e9ri\u00e1m a rakovine"},"content":{"rendered":"<p style=\"text-align:justify\">Ve\u013ek\u00e1 \u010das\u0165 v\u00fdskumu vo svete sa orientuje na vyv\u00edjanie nov\u00fdch druhov lie\u010div, \u010di u\u017e s antimikrobi\u00e1lnymi, protirakovinov\u00fdmi \u010di \u010fal\u0161\u00edmi inhibi\u010dn\u00fdmi \u00fa\u010dinkami. Ide o nov\u00e9 zl\u00fa\u010deniny prechodn\u00fdch kovov s organick\u00fdmi molekulami. Aj pracovn\u00e1 skupina <a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.vargova\/\" target=\"_blank\" rel=\"noopener\"><strong>doc. RNDr. Zuzany Vargovej, Ph.D.<\/strong><\/a> na <strong>Katedre anorganickej ch\u00e9mie<\/strong> Pr\u00edrodovedeckej fakulty UPJ\u0160 v Ko\u0161iciach sa zameriava na pr\u00edpravu a charakteriz\u00e1ciu nov\u00fdch, preva\u017ene strieborn\u00fdch a zino\u010dnat\u00fdch koordina\u010dn\u00fdch zl\u00fa\u010den\u00edn s biologick\u00fdmi \u00fa\u010dinkami. <strong>Ve\u013emi zauj\u00edmav\u00e9 v\u00fdsledky,<\/strong> z\u00edskan\u00e9 v spolupr\u00e1ci nielen s vedcami z \u010fal\u0161\u00edch pracov\u00edsk UPJ\u0160 ale aj \u010fal\u0161\u00edch univerz\u00edt (Univerzita Karlova v Prahe, Univerzita veterin\u00e1rskeho lek\u00e1rstva a farm\u00e1cie v Ko\u0161iciach), <strong>boli publikovan\u00e9<\/strong> v prest\u00ed\u017enom \u010dasopise <strong>Dalton Transactions (Q1)<\/strong>.\u00a0<\/p>\n<p style=\"text-align:justify\"><strong>Dve nov\u00e9 pripraven\u00e9 strieborn\u00e9 zl\u00fa\u010deniny<\/strong> s aminokyselinami, ako organick\u00fdmi biomolekulami, <strong>vykazuj\u00fa v\u00fdrazn\u00e9 antibakteri\u00e1lne a protirakovinov\u00e9 \u00fa\u010dinky<\/strong>. Efekt pripraven\u00fdch l\u00e1tok sa prejav\u00ed v potla\u010den\u00ed rastu zl\u00fdch patog\u00e9nnych bakt\u00e9ri\u00ed, ako aj chor\u00fdch rakovinov\u00fdch buniek, zatia\u013e \u010do telu prospe\u0161n\u00e9 probiotick\u00e9 bakt\u00e9rie a zdrav\u00e9 bunky pre\u017e\u00edvaj\u00fa \u010falej bez poru\u0161enia.<\/p>\n<p style=\"text-align:justify\"><strong>Z pozoruhodn\u00fdch v\u00fdsledkov pr\u00e1ce Rendo\u0161ov\u00e1 et al. (2021)<\/strong> m\u00f4\u017eeme napr\u00edklad vybra\u0165 to, \u017ee pripraven\u00fd strieborn\u00fd komplex AgAsp v n\u00edzkej koncentr\u00e1cii zastavuje rast E. coli a S. aureus bez ovplyvnenia \u017eivotaschopnosti \u0161tudovan\u00fdch laktobacilov. Z\u00e1rove\u0148 protirakovinov\u00e1 aktivita strieborn\u00fdch zl\u00fa\u010den\u00edn bola porovnate\u013en\u00e1 a dokonca pri niektor\u00fdch typoch rakovinov\u00fdch l\u00ednii aj vy\u0161\u0161ia ako aktivita s\u00fa\u010dasne pou\u017e\u00edvan\u00e9ho lie\u010diva &#8211; \u00a0cisplatiny.\u00a0<\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\" src=\"http:\/\/www.upjs.sk\/\/app\/uploads\/sites\/10\/2022\/09\/zluc_striebra_aktual.jpg\" style=\"width:90%\" \/><\/p>\n<p style=\"text-align:justify\"><strong>Biologick\u00fd potenci\u00e1l t\u00fdchto zl\u00fa\u010den\u00edn je vysok\u00fd<\/strong>, \u010do potvrdzuj\u00fa aj \u010fal\u0161ie \u0161t\u00fadie zahrnut\u00e9 v \u010dl\u00e1nku Rendo\u0161ov\u00e1 \u00a0et al. (2021) ako \u0161t\u00fadium stability t\u00fdchto zl\u00fa\u010den\u00edn, interak\u010dn\u00e9 \u0161t\u00fadie s DNA, ako aj \u0161t\u00fadie zmien v bunkovom cykle. <strong>Pou\u017eitie t\u00fdchto strieborn\u00fdch zl\u00fa\u010den\u00edn ako potenci\u00e1lnych lie\u010div je ve\u013emi perspekt\u00edvne a aktu\u00e1lne prebiehaj\u00fa ich \u010fal\u0161ie testovania<\/strong>.<\/p>\n<p style=\"text-align:justify\">Rendo\u0161ov\u00e1, M., Gyepes, R., Cinge\u013eov\u00e1 Maru\u0161\u010d\u00e1kov\u00e1, \u00a0I., Mudro\u0148ov\u00e1, D., Sabolov\u00e1, D., Kello, M., Vilkov\u00e1, \u00a0M., Alm\u00e1\u0161i, M., Hunto\u0161ov\u00e1, V., Zemek, O., Vargov\u00e1, Z. (2021). An in vitro selective inhibitory effect of silver(i) aminoacidates against bacteria and intestinal cell lines and elucidation of the mechanism of action by means of DNA binding properties, DNA cleavage and cell cycle arrest. Dalton Transactions, <strong>50, 936-953,<\/strong> <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2021\/DT\/D0DT03332D#!divAbstract\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1039\/D0DT03332D<\/a><br \/>\n\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p style=\"text-align:justify\">Ve\u013ek\u00e1 \u010das\u0165 v\u00fdskumu vo svete sa orientuje na vyv\u00edjanie nov\u00fdch druhov lie\u010div s antimikrobi\u00e1lnymi, protirakovinov\u00fdmi \u010di \u010fal\u0161\u00edmi inhibi\u010dn\u00fdmi \u00fa\u010dinkami. Aj pracovn\u00e1 skupina <a href=\"https:\/\/www.upjs.sk\/PF\/zamestnanec\/zuzana.vargova\/\" target=\"_blank\" rel=\"noopener\">doc. RNDr. Zuzany Vargovej, Ph.D<\/a>. na Katedre anorganickej ch\u00e9mie PF UPJ\u0160 sa zameriava na pr\u00edpravu a charakteriz\u00e1ciu nov\u00fdch, preva\u017ene strieborn\u00fdch a zino\u010dnat\u00fdch koordina\u010dn\u00fdch zl\u00fa\u010den\u00edn<\/p>\n","protected":false},"author":1,"featured_media":16430,"menu_order":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}"},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-16428","cpt_aktualne_spravy","type-cpt_aktualne_spravy","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nov\u00e9 zl\u00fa\u010deniny striebra proti bakt\u00e9ri\u00e1m a rakovine - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nov\u00e9 zl\u00fa\u010deniny striebra proti bakt\u00e9ri\u00e1m a rakovine - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"Ve\u013ek\u00e1 \u010das\u0165 v\u00fdskumu vo svete sa orientuje na vyv\u00edjanie nov\u00fdch druhov lie\u010div s antimikrobi\u00e1lnymi, protirakovinov\u00fdmi \u010di \u010fal\u0161\u00edmi inhibi\u010dn\u00fdmi \u00fa\u010dinkami. Aj pracovn\u00e1 skupina doc. RNDr. Zuzany Vargovej, Ph.D. na Katedre anorganickej ch\u00e9mie PF UPJ\u0160 sa zameriava na pr\u00edpravu a charakteriz\u00e1ciu nov\u00fdch, preva\u017ene strieborn\u00fdch a zino\u010dnat\u00fdch koordina\u010dn\u00fdch zl\u00fa\u010den\u00edn\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/\" \/>\n<meta property=\"og:site_name\" content=\"Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-28T12:16:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2022\/09\/veda_chemia.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"612\" \/>\n\t<meta property=\"og:image:height\" content=\"344\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Predpokladan\u00fd \u010das \u010d\u00edtania\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 min\u00faty\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/\",\"url\":\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actual-news\/24773\/\",\"name\":\"Nov\u00e9 zl\u00fa\u010deniny striebra proti bakt\u00e9ri\u00e1m a rakovine - 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