{"id":70865,"date":"2024-07-10T13:04:14","date_gmt":"2024-07-10T12:04:14","guid":{"rendered":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/actuality\/ustav-chemickych-vied-na-obalke-casopisu-dalton-transactions-q1\/"},"modified":"2024-07-10T13:09:48","modified_gmt":"2024-07-10T12:09:48","slug":"ustav-chemickych-vied-na-obalke-casopisu-dalton-transactions-q1","status":"publish","type":"cpt_aktuality","link":"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/en\/actuality\/ustav-chemickych-vied-na-obalke-casopisu-dalton-transactions-q1\/","title":{"rendered":"Institute of Chemistry on the cover of Dalton Transactions (Q1)"},"content":{"rendered":"\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<style>.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col,.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col{flex-direction:column;}.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column70865_5f9dd9-01{position:relative;}@media all and (max-width: 1024px){.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column70865_5f9dd9-01 > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column70865_5f9dd9-01\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\">The field of modern medicine faces new challenges in the fight against multi-resistance of pathogenic microorganisms as well as cancer cells, which cause serious and life-threatening diseases all over the world.<\/p>\n\n\n<style>.kb-row-layout-id70865_d47dbe-83 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id70865_d47dbe-83 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id70865_d47dbe-83 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);grid-template-columns:minmax(0, calc(40% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)))minmax(0, calc(60% - ((var(--global-kb-gap-md, 2rem) * 1 )\/2)));}.kb-row-layout-id70865_d47dbe-83 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id70865_d47dbe-83 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr) minmax(0, 2fr);}}@media all and (max-width: 767px){.kb-row-layout-id70865_d47dbe-83 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id70865_d47dbe-83 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-right-golden kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column70865_40f277-aa > .kt-inside-inner-col,.kadence-column70865_40f277-aa > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column70865_40f277-aa > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column70865_40f277-aa > .kt-inside-inner-col{flex-direction:column;}.kadence-column70865_40f277-aa > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column70865_40f277-aa > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column70865_40f277-aa{position:relative;}@media all and (max-width: 1024px){.kadence-column70865_40f277-aa > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column70865_40f277-aa > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column70865_40f277-aa\"><div class=\"kt-inside-inner-col\"><style>.kb-image70865_82bd5f-ed .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image70865_82bd5f-ed size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"467\" height=\"600\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2024\/07\/Dalton-Transactions_Vargova.png\" alt=\"\" class=\"kb-img wp-image-70845\" srcset=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2024\/07\/Dalton-Transactions_Vargova.png 467w, https:\/\/www.upjs.sk\/app\/uploads\/sites\/10\/2024\/07\/Dalton-Transactions_Vargova-234x300.png 234w\" sizes=\"auto, (max-width: 467px) 100vw, 467px\" \/><\/figure>\n<\/div><\/div>\n\n\n<style>.kadence-column70865_098dab-dd > .kt-inside-inner-col,.kadence-column70865_098dab-dd > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column70865_098dab-dd > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column70865_098dab-dd > .kt-inside-inner-col{flex-direction:column;}.kadence-column70865_098dab-dd > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column70865_098dab-dd > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column70865_098dab-dd{position:relative;}@media all and (max-width: 1024px){.kadence-column70865_098dab-dd > .kt-inside-inner-col{flex-direction:column;}}@media all and (max-width: 767px){.kadence-column70865_098dab-dd > .kt-inside-inner-col{flex-direction:column;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column70865_098dab-dd\"><div class=\"kt-inside-inner-col\">\n<p class=\"has-text-align-justify\">The scientific team of <a href=\"https:\/\/www.upjs.sk\/en\/PF\/employee\/zuzana.vargova\/\"><strong>prof. RNDr. Zuzana Vargov\u00e1, Ph.D.<\/strong><\/a> at the Department of Inorganic Chemistry, <strong>Institute of Chemistry<\/strong>, Faculty of Science, is focused on the synthesis and characterization of new bioavailable, predominantly silver complexes, since silver ions themselves have proven antimicrobial and, in recent years, anti-neoplastic effects. The research group in cooperation with Charles University in Prague, University of Veterinary Medicine and Pharmacy in Ko\u0161ice, Institute of Physical Chemistry of the CAS in Prague and Faculty of Medicine UPJ\u0160 in Ko\u0161ice prepared and characterized two new silver coordination compounds that show promising in vitro and in ovo results. This results were published in the prestigious scientific journal <strong>Dalton Transactions (Q1)<\/strong>. The new experimental-theoretical approach to the correlation of chemical, biological and pharmaceutical parameters interested the editor team of the journal and they decided to provide space for the presentation of this work on the cover of the magazine as well. Based on the experimental results, it can be concluded that the prepared AgPro and AgHyp silver complexes in low concentration effectively stop the growth of B. cereus and S. aureus bacteria, while their antibacterial activity is comparable to the effect of silver sulfadizin.<\/p>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n<p class=\"has-text-align-justify\">At the same time, the anticancer activity of the mentioned silver compounds was significantly higher even in the MDA-MB-231 cancer line than the activity of the simultaneously used drug &#8211; cisplatin. Among other things, the study of the potential vasoirritation of the prepared silver complexes demonstrated the safety of intravenous administration of these substances.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">Kuzderov\u00e1, G., Sovov\u00e1, S., Rendo\u0161ov\u00e1, M., Gyepes, R., Sabolov\u00e1, D., Ko\u017e\u00e1rov\u00e1, I., Bal\u00e1\u017eov\u00e1, \u013d., Vilkov\u00e1, M., Kello, M.,  Li\u0161ka, A., Vargov\u00e1, Z. (2024). Influence of proline and hydroxyproline as antimicrobial and anticancer peptide components on the silver(i) ion activity: structural and biological evaluation with a new theoretical and experimental SAR approach. <\/p>\n\n\n<style>.wp-block-kadence-column.kb-section-dir-horizontal > .kt-inside-inner-col > .kt-info-box70865_6b882d-91 .kt-blocks-info-box-link-wrap{max-width:unset;}.kt-info-box70865_6b882d-91 .kt-blocks-info-box-link-wrap{border-top:0px solid var(--global-palette7, #eeeeee);border-right:0px solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px solid var(--global-palette7, #eeeeee);border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;background:#ffffff;padding-top:var(--global-kb-spacing-xs, 1rem);padding-right:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);padding-left:var(--global-kb-spacing-xs, 1rem);}.kt-info-box70865_6b882d-91 .kadence-info-box-icon-container .kt-info-svg-icon, .kt-info-box70865_6b882d-91 .kt-info-svg-icon-flip, .kt-info-box70865_6b882d-91 .kt-blocks-info-box-number{font-size:20px;}.kt-info-box70865_6b882d-91 .kt-blocks-info-box-media{color:#008338;border-radius:200px;border-top-width:0px;border-right-width:0px;border-bottom-width:0px;border-left-width:0px;padding-top:9px;padding-right:9px;padding-bottom:9px;padding-left:9px;margin-top:0px;margin-right:5px;margin-bottom:0px;margin-left:0px;}.kt-info-box70865_6b882d-91 .kt-blocks-info-box-media .kadence-info-box-image-intrisic img{border-radius:200px;}.kt-info-box70865_6b882d-91 .kt-blocks-info-box-link-wrap:hover .kt-blocks-info-box-media{color:#C19152;}.kt-info-box70865_6b882d-91 .kt-infobox-textcontent h2.kt-blocks-info-box-title{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;margin-top:5px;margin-right:0px;margin-bottom:10px;margin-left:0px;}.kt-info-box70865_6b882d-91 .kt-infobox-textcontent .kt-blocks-info-box-text{color:#000000;}.kt-info-box70865_6b882d-91 .kt-blocks-info-box-learnmore{background:transparent;border-width:0px 0px 0px 0px;padding-top:4px;padding-right:8px;padding-bottom:4px;padding-left:8px;margin-top:10px;margin-right:0px;margin-bottom:10px;margin-left:0px;}@media all and (max-width: 1024px){.kt-info-box70865_6b882d-91 .kt-blocks-info-box-link-wrap{border-top:0px solid var(--global-palette7, #eeeeee);border-right:0px solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px solid var(--global-palette7, #eeeeee);}}@media all and (max-width: 767px){.kt-info-box70865_6b882d-91 .kt-blocks-info-box-link-wrap{border-top:0px solid var(--global-palette7, #eeeeee);border-right:0px solid var(--global-palette7, #eeeeee);border-bottom:0px solid var(--global-palette7, #eeeeee);border-left:0px solid var(--global-palette7, #eeeeee);}}<\/style>\n<div class=\"wp-block-kadence-infobox kt-info-box70865_6b882d-91\"><a class=\"kt-blocks-info-box-link-wrap info-box-link kt-blocks-info-box-media-align-left kt-info-halign-left\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/doi.org\/10.1039\/D4DT00389F\"><div class=\"kt-blocks-info-box-media-container\"><div class=\"kt-blocks-info-box-media kt-info-media-animate-none\"><div class=\"kadence-info-box-icon-container kt-info-icon-animate-none\"><div class=\"kadence-info-box-icon-inner-container\"><span class=\"kb-svg-icon-wrap kb-svg-icon-fe_externalLink kt-info-svg-icon\"><svg viewBox=\"0 0 24 24\"  fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"  aria-hidden=\"true\"><path d=\"M18 13v6a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2V8a2 2 0 0 1 2-2h6\"\/><polyline points=\"15 3 21 3 21 9\"\/><line x1=\"10\" y1=\"14\" x2=\"21\" y2=\"3\"\/><\/svg><\/span><\/div><\/div><\/div><\/div><div class=\"kt-infobox-textcontent\"><p class=\"kt-blocks-info-box-text\"><strong><em>Dalton Trans.<\/em><\/strong>, 2024, <strong>53<\/strong>, 10834-10850.<\/p><\/div><\/a><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The scientific team of prof. RNDr. Zuzana Vargov\u00e1, Ph.D. at the Department of Inorganic Chemistry, Institute of Chemistry, Faculty of Science, is focused on the synthesis and characterization of new bioavailable, predominantly silver complexes, since silver ions themselves have proven antimicrobial and, in recent years, anti-neoplastic effects. <\/p>\n","protected":false},"author":25,"featured_media":70862,"template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-70865","cpt_aktuality","type-cpt_aktuality","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":"","poradie_clanku":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Institute of Chemistry on the cover of Dalton Transactions (Q1) - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/prirodovedecka-fakulta\/en\/actuality\/ustav-chemickych-vied-na-obalke-casopisu-dalton-transactions-q1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Institute of Chemistry on the cover of Dalton Transactions (Q1) - Pr\u00edrodovedeck\u00e1 fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"The scientific team of prof. 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