{"id":13539,"date":"2021-12-06T07:50:16","date_gmt":"2021-12-06T07:50:16","guid":{"rendered":"https:\/\/www.upjs.sk\/pracoviska\/tip\/events\/webinar-190521\/"},"modified":"2022-10-05T13:23:00","modified_gmt":"2022-10-05T13:23:00","slug":"webinar-190521","status":"publish","type":"cpt_podujatia","link":"https:\/\/www.upjs.sk\/pracoviska\/tip\/events\/webinar-190521\/","title":{"rendered":"„SCIENCE MEETS BUSINESS“ #1: Aplik\u00e1cia zeta potenci\u00e1lu pri v\u00fdvoji biofarmaceutick\u00fdch suspenzi\u00ed"},"content":{"rendered":"

\"\"<\/p>\n

\nD\u00e1tum:<\/span> <\/strong>
\nstreda, 19. m\u00e1j 2021 o 13:30 (d\u013a\u017eka trvania 60 min\u00fat)<\/p>\n

Miesto:<\/span> <\/strong>
\nonline (MS TEAMS)<\/p>\n

Cena:<\/span> <\/strong>
\nbezplatne<\/p>\n

Organiz\u00e1tor:<\/span> <\/strong>
\nTechnologick\u00fd a inova\u010dn\u00fd park UPJ\u0160 (TIP-UPJ\u0160), Centrum interdisciplin\u00e1rnych biovied (CIB)<\/p>\n

Kontakt:<\/strong><\/span>
\nMgr. Slavom\u00edra Hrabovsk\u00e1, T: 0948 985 648, E: slavomira.hrabovska@upjs.sk<\/a><\/p>\n

Technologick\u00fd a inova\u010dn\u00fd park UPJ\u0160 pripravil webin\u00e1r na t\u00e9mu Aplik\u00e1cia zeta potenci\u00e1lu pri v\u00fdvoji biofarmaceutick\u00fdch suspenzi\u00ed<\/strong><\/p>\n

Anot\u00e1cia:<\/strong><\/span>
\nZeta potenci\u00e1l je mierou ve\u013ekosti elektrostatick\u00e9ho odporu \/ pr\u00ed\u0165a\u017elivosti medzi \u010dasticami a je jedn\u00fdm zo z\u00e1kladn\u00fdch parametrov, o ktor\u00fdch je zn\u00e1me, \u017ee ovplyv\u0148uj\u00fa stabilitu koloid\u00e1lneho syst\u00e9mu. Meranie a kvantifik\u00e1cia zeta potenci\u00e1lu prin\u00e1\u0161a podrobn\u00fd poh\u013ead na pr\u00ed\u010diny polydisperzie, agreg\u00e1cie alebo vlo\u010dkovania napr. u monoklon\u00e1lnych protil\u00e1tok a vakc\u00edn. Z\u00edskan\u00e9 inform\u00e1cie m\u00f4\u017eeme pou\u017ei\u0165 na zlep\u0161enie formul\u00e1cie aj in\u00fdch disperzi\u00ed, emulzi\u00ed a suspenzi\u00ed. Meranie zeta potenci\u00e1lu je jedn\u00fdm zo sp\u00f4sobov ako skr\u00e1ti\u0165 testovanie koloid\u00e1lnej stability\u00a0 a to hlavne zn\u00ed\u017een\u00edm po\u010dtu vhodn\u00fdch formul\u00e1ci\u00ed, a t\u00fdm skr\u00e1ti\u0165 \u010das a n\u00e1klady na testovanie, ako aj pred\u013a\u017ei\u0165 trvanlivos\u0165 produktu.
\nV r\u00e1mci n\u00e1\u0161ho aktu\u00e1lneho v\u00fdskumu sme sledovali zeta potenci\u00e1l hydrof\u00f3bneho povrchu a jeho vplyv na adsorpciu dvoch terapeutick\u00fdch protil\u00e1tok IgG1 \uf06b-typu, herceptin a rituximab. Napriek tomu, \u017ee spom\u00ednan\u00e9 protil\u00e1tky s\u00fa sekven\u010dne ve\u013emi podobn\u00e9 (identita >80%), adsorpcia protil\u00e1tok v pr\u00edtomnosti excipientov prebieha odli\u0161ne. V pr\u00edpade rituximabu je pas\u00edvna adsorpcia na pevn\u00fd povrch ovplyvnen\u00e1 akumul\u00e1ciou vysoko polarizovate\u013en\u00fdch ani\u00f3nov v bezprostrednej bl\u00edzkosti protil\u00e1tky v d\u00f4sledku vz\u00e1jomn\u00fdch ne-elektostatick\u00fdch dispezn\u00fdch interakci\u00ed. Pri pr\u00edprave stabilnej formul\u00e1cie rituximabu odpor\u00fa\u010dame zv\u00e1\u017eenie resp. vynechanie excipientov s vysokou hodnotu polarizovate\u013enosti.
\nNa\u0161e v\u00fdsledky poukazuj\u00fa na potrebu individualizovanej kvantifik\u00e1cie zeta potenci\u00e1lu biofarmaceutick\u00fdch suspenzi\u00ed. Stanovenie a interpret\u00e1ciu zeta potenci\u00e1lu vieme uskuto\u010dni\u0165 v r\u00e1mci kontrahovanej slu\u017eby a\/alebo vedeckej spolupr\u00e1ce.<\/p>\n

Predn\u00e1\u0161aj\u00faci bude RNDr. Gabriel \u017dold\u00e1k, PhD.<\/strong> z Centra interdisciplin\u00e1rnych biovied v TIP-UPJ\u0160.<\/p>\n

Cie\u013eov\u00e1 skupina:<\/strong><\/span>
\nStart-upy, Scale-upy, SMEs a vedeck\u00ed pracovn\u00edci, ktor\u00ed vyplnia registra\u010dn\u00fd formul\u00e1r s po\u017eadovan\u00fdmi inform\u00e1ciami.<\/p>\n

Pracovn\u00fd jazyk:<\/strong><\/span>
\nslovensk\u00fd<\/p>\n

Registr\u00e1cia:<\/strong><\/span>
\nRegistrova\u0165 sa m\u00f4\u017eete do 18. m\u00e1ja 2021<\/strong> prostredn\u00edctvom registra\u010dn\u00e9ho formul\u00e1ra.
\n\u00a0<\/p>\n\n\n\n
\u00a0REGISTR\u00c1CIA<\/strong><\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\nOdkaz na webin\u00e1r (prostredn\u00edctvom platformy Microsoft Teams) za\u0161leme zaregistrovan\u00fdm \u00fa\u010dastn\u00edkom v de\u0148 jeho konania.<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

D\u00e1tum: streda, 19. m\u00e1j 2021 o 13:30 (d\u013a\u017eka trvania 60 min\u00fat) Miesto: online (MS TEAMS) Cena: bezplatne Organiz\u00e1tor: Technologick\u00fd a inova\u010dn\u00fd park UPJ\u0160 (TIP-UPJ\u0160), Centrum interdisciplin\u00e1rnych biovied (CIB) Kontakt: Mgr. Slavom\u00edra Hrabovsk\u00e1, T: 0948 985 648, E: slavomira.hrabovska@upjs.sk Technologick\u00fd a inova\u010dn\u00fd park UPJ\u0160 pripravil webin\u00e1r na t\u00e9mu Aplik\u00e1cia zeta potenci\u00e1lu pri v\u00fdvoji biofarmaceutick\u00fdch suspenzi\u00ed Anot\u00e1cia: … \u010c\u00edta\u0165 \u010falej<\/a><\/p>\n","protected":false},"author":1,"featured_media":13540,"menu_order":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}"},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-13539","cpt_podujatia","type-cpt_podujatia","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":"","cpt_udalost_datum_konania":null,"cpt_udalost_datum_koniec":null,"cpt_udalost_miesto_konania":"","cpt_udalost_cas_konania":null},"yoast_head":"\n"SCIENCE MEETS BUSINESS" #1: Aplik\u00e1cia zeta potenci\u00e1lu pri v\u00fdvoji biofarmaceutick\u00fdch suspenzi\u00ed - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/pracoviska\/tip\/events\/webinar-190521\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""SCIENCE MEETS BUSINESS" #1: Aplik\u00e1cia zeta potenci\u00e1lu pri v\u00fdvoji biofarmaceutick\u00fdch suspenzi\u00ed - Technologick\u00fd a inova\u010dn\u00fd park | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"D\u00e1tum: streda, 19. m\u00e1j 2021 o 13:30 (d\u013a\u017eka trvania 60 min\u00fat) Miesto: online (MS TEAMS) Cena: bezplatne Organiz\u00e1tor: Technologick\u00fd a inova\u010dn\u00fd park UPJ\u0160 (TIP-UPJ\u0160), Centrum interdisciplin\u00e1rnych biovied (CIB) Kontakt: Mgr. 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