{"id":30029,"date":"2022-05-11T09:41:31","date_gmt":"2022-05-11T09:41:31","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/root\/patologicka-fyziologia\/historia\/"},"modified":"2023-07-18T08:53:48","modified_gmt":"2023-07-18T07:53:48","slug":"historia","status":"publish","type":"cpt_ustav","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/patologicka-fyziologia\/historia\/","title":{"rendered":"Hist\u00f3ria \u00fastavu patologickej fyziol\u00f3gie"},"content":{"rendered":"<p style=\"text-align:justify; text-indent:2em\">Katedra patologickej fyziol\u00f3gie a experiment\u00e1lnej patol\u00f3gie v Ko\u0161iciach za\u010dala svoju \u010dinnos\u0165 ako jeden v\u00f4bec z prv\u00fdch \u00fastavov pobo\u010dky Lek\u00e1rskej fakulty Univerzity Komensk\u00e9ho v Ko\u0161iciach v okt\u00f3bri 1948. Vedenie \u00fastavu prevzal (od roku 1949 do 1970) po pr\u00edchode z Bratislavsk\u00e9ho \u00fastavu bioch\u00e9mie zanieten\u00fd experiment\u00e1tor MUDr. R. Korec profilovan\u00fd v metabolickom a diabetologickom v\u00fdskume (monografia Metabolizmus 1955), ktor\u00fd tu habilitoval (1956), inauguroval (1962) a z\u00edskal hodnos\u0165 DrSc. (1969). Okrem metabolizmu a diabetol\u00f3gie za\u010dali od polovice 50-tych rokov MUDr. I. Ivan\u010do, MUDr. J. Korp\u00e1\u0161 a MUDr. Z. Tomori (posledn\u00ed 2 docenti v 1965 a 1968), za\u010dali aj s v\u00fdskumom respira\u010dn\u00fdch reflexov, \u010do sa stalo pre nich nesk\u00f4r z\u00e1kladnou v\u00fdskumnou oblas\u0165ou. Prof. Korec spolu s kolegami vyv\u00edjali na katedre aj kreat\u00edvnu pedagogick\u00fa \u010dinnos\u0165 vysoko oce\u0148ovan\u00fa v r\u00e1mci \u010ceskoslovenska. Vznik\u00e1 tu jedna z prv\u00fdch slovensk\u00fdch u\u010debn\u00edc patofyziol\u00f3gie (Korec R.: Patologick\u00e1 fyziol\u00f3gia, 1964). <strong>Prof. MUDr. R. Korec, DrSc.<\/strong> prezentuje v\u00fdsledky \u0161t\u00fadia experiment\u00e1lneho diabetu na medzin\u00e1rodn\u00fdch f\u00f3rach (48 \u0161t\u00e1tov sveta), v medzin\u00e1rodn\u00fdch \u010dasopisoch (celkove 236 vedeck\u00fdch pr\u00e1c). Mnoho zo svojich sk\u00fasenost\u00ed a zahrani\u010dn\u00fdch kontaktov sprostredkoval kolegom. Z\u00edskan\u00e9 experiment\u00e1lne poznatky zhrnul v jedine\u010dnej monogra\ufb01i <em>Experimental Diabetes Mellitus in the Rat (1967)<\/em>. V 70. rokoch napriek zlo\u017eit\u00fdm materi\u00e1lnym podmienkam a finan\u010dnej podpore v\u00fdskumu, prof. Korec uskuto\u010d\u0148uje v Eur\u00f3pe \u00faspe\u0161n\u00e9 transplant\u00e1cie izolovan\u00fdch Langerhansov\u00fdch ostrov\u010dekov do ren\u00e1lnej kapsuly. Obaja, prof. MUDr. J. Korp\u00e1\u0161, DrSc. ako aj prof. MUDr. Z. Tomori, DrSc. pokra\u010dovali v oblasti experiment\u00e1lnej respirol\u00f3gie v Martine. Najv\u00fdznamnej\u0161ie v\u00fdsledky zhrnuli v monografii <em>Korp\u00e1\u0161, J., Tomori, Z.: Cough and other respiratory reflexes (1978)<\/em>. Stali sa prednostami \u00dastavov fyziol\u00f3gie a patologickej fyziol\u00f3gie na Jesseniovej LF UK v Martine. Prof. MUDr. I. Ivan\u010do, CSc. sa stal prednostom \u00dastavu fyziol\u00f3gie na LF UPJ\u0160.<\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/9\/2022\/09\/1.jpg\" style=\"height:330px; width:750px\"><\/p>\n<p style=\"text-align:justify; text-indent:2em\">Pod veden\u00edm <strong>doc. MUDr. J. Vargu, CSc.<\/strong> (1970-1986) sa pracovisko profiluje vo v\u00fdu\u010dbovo-metodickej oblasti. Vznik\u00e1 viacero skr\u00edpt, manu\u00e1lov pre anim\u00e1lne praktick\u00e9 cvi\u010denia s implement\u00e1ciou audiovizu\u00e1lnych pom\u00f4cok (MUDr. P. Dombrovsk\u00fd, MVDr. M. Riemerov\u00e1). Vznik\u00e1 prv\u00e1 samostatn\u00e1 slovensk\u00e1 u\u010debnica etiopatogen\u00e9zy (<em>Varga, J., Oblyva\u010d, J.: V\u0161eobecn\u00e1 patofyziol\u00f3gia, 1979)<\/em>, tvoriaca dvojicu so \u0160peci\u00e1lnou patofyziol\u00f3giou bratislavsk\u00fdch kolegov. Vo v\u00fdskumnej oblasti sa \u00fastav zaoberal \u0161t\u00fadium vz\u0165ahov medzi endo- a exosekr\u00e9ciou pankreasu (Doc. MUDr. A. \u0160ofrankov\u00e1, CSc.) a tie\u017e klinickou bioch\u00e9miou diabetu vr\u00e1tane glyk\u00e1cie bielkov\u00edn (Doc. MUDr. O. R\u00e1cz, CSc.). V\u00fdsledky boli prezentovan\u00e9 v publik\u00e1ci\u00e1ch vr\u00e1tane monografie <em>R\u00e1cz, O. et al.: Glykohemoglob\u00edn, glyk\u00e1cia bielkov\u00edn a diabetes mellitus (1989)<\/em>.<\/p>\n<p style=\"text-align:justify; text-indent:2em\">V rokoch 1986 &#8211; 1990 bol ved\u00facim \u00fastavu <strong>prof. MUDr. Zolt\u00e1n Tomori, DrSc.<\/strong>, ktor\u00fd priniesol sp\u00e4\u0165 \u010das\u0165 respirologick\u00e9ho v\u00fdskum z JLF v Martine. \u00dastav sa zapojil do grantov\u00fdch sch\u00e9m, zahrani\u010dnej kooper\u00e1cie i komputeriz\u00e1cie (1988). Realizuje sa digitalizovan\u00fd zber, prenos a komputerizovan\u00e9 hodnotenie fyziologick\u00fdch d\u00e1t z experimentov (Ing. J. \u010calfa, M. Kurpas). Realizoval sa v\u00fdskum mechanizmov kardio-respira\u010dn\u00e9ho hypoxick\u00e9ho zlyhania (MUDr. R. Tk\u00e1\u010dov\u00e1, CSc.), reflexy vyvolan\u00e9 tlakov\u00fdmi podnetmi do HDC a ich resuscita\u010dn\u00fd \u00fa\u010dinok (MUDr. V. Doni\u010d), cerebr\u00e1lna elektrofyziol\u00f3gia po\u010das hypoxie a isch\u00e9mie (MUDr. M. Jur\u010do, MUDr. Roman Be\u0148a\u010dka), anoxicky a ichemicky navoden\u00e9 poruchy respira\u010dn\u00e9ho rytmu a resuscita\u010dn\u00e1 \u00fa\u010dinnos\u0165 reflexov z nazofaryngu a trigeminovej oblasti (MUDr. R. Be\u0148a\u010dka). Prebehlo viacero dlhodob\u00fdch plodn\u00fdch v\u00fdskumn\u00fdch st\u00e1\u017e\u00ed pracovn\u00edkov v zahrani\u010d\u00ed (1991 \u2013 1993; Nemecko, USA).<\/p>\n<p style=\"text-align:justify; text-indent:2em\">Ved\u00facou \u00fastavu v rokoch 1990 \u2013 1992 bola <strong>doc. MUDr. A. \u0160ofrankov\u00e1, CSc.<\/strong>, ktor\u00e1 vykon\u00e1vala aj funkciu prorektorky. \u00dastav pokra\u010duje v eduka\u010dnej trad\u00edcii. Vych\u00e1dza dielo <em>Varga, J., \u0160ofrankov\u00e1, A.: Patofyziologick\u00fd atlas (1991)<\/em>. Prof. Korec publikuje v\u00fdsledky dlhoro\u010dn\u00e9ho experiment\u00e1lneho v\u00fdskumu diabetu v monografii <em>Korec, R. : Experimental and Spontaneous Diabetes Mellitus in the Rat and Mouse (1991)<\/em>. Zvy\u0161uje sa d\u00f4raz na skvalitnenie v\u00fdu\u010dbov\u00e9ho procesu. V r\u00e1mci UPJ\u0160 bol \u00fastav medzi prv\u00fdmi (1992), na ktorom sa realizovalo pripojenie na medzin\u00e1rodn\u00fa akademick\u00fa po\u010d\u00edta\u010dov\u00fa sie\u0165 EARN. V rokoch 1990- 1995 sa do v\u00fdskumu dost\u00e1vaj\u00fa na t\u00fa dobu unik\u00e1tne komputerizovan\u00e9 met\u00f3dy zberu a hodnotenia experiment\u00e1lnych d\u00e1t, vr\u00e1tane automatizovan\u00e9ho hodnotenia pneumotachografick\u00fdch d\u00e1t (MUDr. V. Doni\u010d, CSc., M. Kurpas), spektr\u00e1lnej anal\u00fdzy EMG a EEG a sekven\u010dn\u00e9ho hodnotenia nat\u00edvnej a evokovanej mozgovej aktivity po\u010das hypoxie and isch\u00e9mie in vivo (MUDr. R. Be\u0148a\u010dka, CSc., RNDr. J. G\u00e1lik, CSc. (NF\u00da SAV).<\/p>\n<p style=\"text-align:justify; text-indent:2em\">V obdob\u00ed od roku 1992 do roku 2016 bol prednostom \u00dastavu patologickej fyziol\u00f3gie <strong>doc. MUDr. Oliver R\u00e1cz, CSc.<\/strong>, ktor\u00fd od roku 1997 do 2001 aj zast\u00e1val funkciu prorektora UPJ\u0160. Organiza\u010dne najv\u00fdraznej\u0161ou zmenou je za\u010diatok v\u00fdu\u010dby zahrani\u010dn\u00fdch \u0161tudentov v anglickom jazyku (1995\/1996) \u010do pokra\u010duje doposia\u013e. Ako reakcia vznikli 2-dielne skript\u00e1 v\u0161eobecnej patofyziol\u00f3gie v anglickom jazyku <em>R\u00e1cz, O. et al.: Compendium of general pathological physiology I, II (1995)<\/em> prelo\u017een\u00e9 i do sloven\u010diny<em> (R\u00e1cz, O. a spol.: V\u0161eobecn\u00e1 patologick\u00e1 fyziol\u00f3gia, 1996)<\/em>. V 90-tych rokoch \u00fastav pokra\u010duje v diabetologickom v\u00fdskume (prof. Korec, Doc. MVDr. F. Ni\u0161tiar, CSc.) i v \u0161t\u00fadiu oxida\u010dn\u00e9ho po\u0161kodenia a celkovej antioxida\u010dnej ochrany (Doc. R\u00e1cz). Od polovice 90-tych rokov i legislat\u00edvnymi zmenami doch\u00e1dza k redukcii re\u00e1lnej praktickej v\u00fdu\u010dby na anim\u00e1lnych modeloch. T\u00e1 je postupne nahraden\u00e1 semin\u00e1rmi a tutori\u00e1lmi s vyu\u017eit\u00edm audio-vizu\u00e1lnej techniky. \u00dastav v \u0161k. roku 1997\/1998 za\u010das s v\u00fdu\u010dbou Patobioch\u00e9mie (Doc. R\u00e1cz) nesk\u00f4r obsahovo prebudovanom na molekul\u00e1rne a celul\u00e1rne aspekty patogen\u00e9zy (Dr. Be\u0148a\u010dka). Vznikol povinn\u00fd predmet <em>Molekul\u00e1rne z\u00e1klady chorobn\u00fdch procesov (1998)<\/em> a u\u010debn\u00e9 texty <em>Be\u0148a\u010dka, R. et al. &amp; Ni\u0161tiar, F. et al.: Z\u00e1klady molekul\u00e1rnej medic\u00edny (2004, 2005)<\/em>.<\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/9\/2022\/09\/2.jpg\" style=\"height:250px; width:755px\"><\/p>\n<p style=\"text-align:justify; text-indent:2em\">V rokoch 1995 -2000, v\u010faka sk\u00fasenostiam s experiment\u00e1lnym modelovan\u00edm apnoick\u00fdch stavov, etablovaniu medzin\u00e1rodnej spolupr\u00e1ce (ERS) a grantu TEMPUS (Tomori a spol. 1995-1998) do\u0161lo k postupn\u00e9mu presmerov\u00e1vaniu v\u00fdskumu k praktick\u00fdm aplik\u00e1ci\u00e1m a klinicko-fyziologick\u00e9mu \u0161t\u00fadiu sp\u00e1nkov\u00fdch apnoick\u00fdch stavov (prof. Tomori, Dr. Doni\u010d, Dr. Be\u0148a\u010dka). V Ko\u0161iciach vznik\u00e1 prv\u00e9 z troch sp\u00e1nkov\u00e9 laborat\u00f3rium na Slovensku (prof. Tomori, Dr. Doni\u010d). Vznik\u00e1 i odborn\u00e1 monografia<em> Tomori, Z. a kol. : Z\u00e1klady sp\u00e1nkovej medic\u00edny (1999)<\/em>. S odchodom prof. Tomoriho a Doc. Doni\u010da sa v\u00fdskumn\u00e1 problematika sp\u00e1nkovej medic\u00edny v r. 2003 presunula na \u00dastav fyziol\u00f3gie.<\/p>\n<p style=\"text-align:justify; text-indent:2em\">Od roku 2004 sa za\u010dala rozv\u00edja\u0165 v\u00fdskumn\u00e1 tematika chronickej expoz\u00edcie subtoxick\u00fdmi d\u00e1vkami \u0165a\u017ek\u00fdch kovov na anim\u00e1lnych modeloch (prof. Ni\u0161tiar, nesk\u00f4r MVDr. Lov\u00e1sov\u00e1, PhD.; koncom dek\u00e1dy MVDr. J. Nov\u00e1kov\u00e1, PhD., Ing. Cimbol\u00e1kov\u00e1, PhD.). Pokra\u010dovalo sa v \u0161t\u00fadiu oxida\u010dn\u00e9ho po\u0161kodenia a ochrany aplika\u010dne pokra\u010dovali aj v \u010fal\u0161ej dek\u00e1de v experimente (Dr. Lov\u00e1sov\u00e1) i pri kardi\u00e1lnej isch\u00e9mie u \u013eud\u00ed (MUDr. Sedl\u00e1kov\u00e1, PhD.). V rokoch 2003-2012 pokra\u010duje v\u00fdskum trigemino-vagov\u00fdch reflexov, meranie auton\u00f3mnych kardi\u00e1lnych indexov a respira\u010dn\u00fdch zmien pri fyzickej aktivite (Doc. Be\u0148a\u010dka) vr\u00e1tane mo\u017enosti reverzie supraventrikul\u00e1rnych arytmi\u00ed (Doc. Be\u0148a\u010dka, Dr. Sedl\u00e1kov\u00e1). Pribudla v\u00fdu\u010dba Patofyziol\u00f3gie v nelek\u00e1rskych smeroch \u2013 v O\u0161etrovate\u013estve, Fyzioterapii, Verejnom zdravotn\u00edctve a P\u00f4rodnej asistencii. Vznikaj\u00fa krat\u0161ie u\u010debn\u00e9 texty <em>R\u00e1cz, O. a spol.: Z\u00e1klady patologickej fyziol\u00f3gie (2006)<\/em> ur\u010den\u00e9 pre tieto odbory. Po akredit\u00e1cii odboru vznik\u00e1 v roku 2007 odborov\u00e1 komisia pre obhajobu dizerta\u010dn\u00fdch pr\u00e1c v odbore Norm\u00e1lna a patologick\u00e1 fyziol\u00f3gia na LF UPJ\u0160 (prof. Ni\u0161tiar, garant; doc. Be\u0148a\u010dka, predseda).<\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/9\/2022\/09\/3.jpg\" style=\"height:300px; width:516px\"><\/p>\n<p style=\"text-align:justify; text-indent:2em\">V roku 2009 sa doc. Be\u0148a\u010dka stal ved\u00facim redaktorom fakultn\u00e9ho vedecko-odborn\u00e9ho \u010dasopisu Folia Medica Cassoviensia. Vytv\u00e1ra nov\u00fd dizajn a obsahov\u00fa n\u00e1pl\u0148. \u010casopis za\u010dal publikova\u0165 suplement\u00e1 Medzin\u00e1rodn\u00fdch \u0161tudentsk\u00fdch vedeck\u00fdch konferenci\u00ed organizovan\u00fdch Lek\u00e1rskou fakultou v Ko\u0161iciach. V roku 2010 \u00fastav organizuje <em>18. Konferenciu \u010desk\u00fdch a slovensk\u00fdch patofyziol\u00f3gov<\/em> (Doc. Be\u0148a\u010dka a spol.). V r\u00e1mci projektov \u0161truktur\u00e1lnych fondov EU (2010-2014) vznik\u00e1 v r. 2012<em> Laborat\u00f3rium aplikovanej fyziol\u00f3gie<\/em> (Doc. Be\u0148a\u010dka a spol.).<\/p>\n<p style=\"text-align:justify; text-indent:2em\">Od roku 2016 sa stal ved\u00facim \u00fastavu <strong>Doc. MUDr. Roman Be\u0148a\u010dka, CSc.<\/strong> Roz\u0161iruje sa, modernizuje sa a unifikuje sa obsahov\u00e1 i form\u00e1lna n\u00e1pl\u0148 v\u00fdu\u010dby v slovenskom a anglickom jazyku (demon\u0161tra\u010dn\u00e9 videopraktik\u00e1, simul\u00e1tory), a to v jednotliv\u00fdch pododboroch lek\u00e1rskeho i nelek\u00e1rskeho kurikula. Implementuje sa celkom nov\u00fd syst\u00e9m kreditn\u00fdch testov (ot\u00e1zky ano-nie + kv\u00edzov\u00e9 otvoren\u00e9 ot\u00e1zky) i sk\u00fa\u0161ok (elekronick\u00e9 losovanie). Od roku 2015 \u00fastav v\u00fdskumne spolupracoval na tematike monitorovania cerebr\u00e1lnej hypoxie pomocou neinvaz\u00edvnych techn\u00edk (NIRS, aEEG) (MUDr. Rusn\u00e1kov\u00e1, Doc. Be\u0148a\u010dka) s neonatologickou klinikou (MUDr. Krcho, PhD.) s akt\u00edvnou \u00fa\u010das\u0165ou na svetovom patofyziologickom kongrese v Bratislave. \u00dastav tie\u017e spolupracoval pri hodnoten\u00ed komplik\u00e1ci\u00ed diabetu ako je gastropar\u00e9za a neuropatie (MUDr. L. \u0160alamonov\u00e1-Blichov\u00e1, PhD., Doc. R\u00e1cz) s odd. Nukle\u00e1rnej medic\u00edny a vplyvu diabetu na zmeny metabolizmu cukrov a tukov po\u010das gravidity vr. gest\u00f3zy (MUDr. M. Breni\u0161in, PhD., Doc. R\u00e1cz).<\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\" src=\"https:\/\/www.upjs.sk\/app\/uploads\/sites\/9\/2022\/09\/4.jpg\" style=\"height:300px; width:510px\"><\/p>\n<p style=\"text-align:justify; text-indent:2em\">\u00dastav pravidelne a akt\u00edvne participuje na predn\u00e1\u0161kach i v programovom v\u00fdbore (Doc. R\u00e1cz, Doc. Be\u0148a\u010dka) ka\u017edoro\u010dn\u00fdch Vedeck\u00fdch m\u00edtingov spoluorganizovan\u00fdch Slovenskou diabetologickou spolo\u010dnos\u0165ou venovan\u00fdch pamiatke a vedeck\u00e9mu odkazu prof. Koreca, a to od roku 2003. Od roku 2020 \u00fastav (Mgr. D. Szab\u00f3ov\u00e1) tie\u017e intenz\u00edvnej\u0161ie spolupracuje na problematike molekul\u00e1rnych princ\u00edpov v patogen\u00e9ze ochoren\u00ed \u2013 metabolomike, proteomike a lipidomike s \u00dastavom experiment\u00e1lnej medic\u00edny. V roku 2020 bola odovzdan\u00e1 do tla\u010de plnofarebn\u00e1 ilustrovan\u00e1 u\u010debnica: <em>Be\u0148a\u010dka et al.: V\u0161eobecn\u00e1 patofyziol\u00f3gia. Mechanizmy vzniku chor\u00f4b, 2021)<\/em>, pre v\u0161eobecn\u00e9 a zubn\u00e9 lek\u00e1rstvo a nadv\u00e4zuj\u00faca na tie najlep\u0161ie eduka\u010dn\u00e9 trad\u00edcie \u00fastavu a n\u00e1sledne koncom r. 2021 u\u010debnica: <em>Be\u0148a\u010dka et al.: Patofyziol\u00f3gia pre zdravotn\u00edcke odbory,2022<\/em>.<\/p>\n<p><span style=\"float:right\">apr\u00edl 2022<\/span>Doc. MUDr. Roman Be\u0148a\u010dka, CSc.<\/p>\n","protected":false},"author":1,"featured_media":14097,"parent":30020,"menu_order":1,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-30029","cpt_ustav","type-cpt_ustav","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hist\u00f3ria \u00fastavu patologickej fyziol\u00f3gie - Lek\u00e1rska fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/patologicka-fyziologia\/historia\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hist\u00f3ria \u00fastavu patologickej fyziol\u00f3gie - Lek\u00e1rska fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"Katedra patologickej fyziol\u00f3gie a experiment\u00e1lnej patol\u00f3gie v Ko\u0161iciach za\u010dala svoju \u010dinnos\u0165 ako jeden v\u00f4bec z prv\u00fdch \u00fastavov pobo\u010dky Lek\u00e1rskej fakulty Univerzity Komensk\u00e9ho v Ko\u0161iciach v okt\u00f3bri 1948. 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