{"id":29235,"date":"2023-02-18T02:31:21","date_gmt":"2023-02-18T01:31:21","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/root\/histologia-a-embryologia\/"},"modified":"2024-09-26T08:05:31","modified_gmt":"2024-09-26T07:05:31","slug":"histologia-a-embryologia","status":"publish","type":"cpt_ustav","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/ustav\/histologia-a-embryologia\/","title":{"rendered":"\u00dastav histol\u00f3gie a embryol\u00f3gie"},"content":{"rendered":"\n
\u0160rob\u00e1rova 2, 041 80 Ko\u0161ice<\/p>\n\n\n\n
\u00dastav histol\u00f3gie a embryol\u00f3gie zabezpe\u010duje v\u00fdu\u010dbu vo v\u0161etk\u00fdch \u0161tudijn\u00fdch odboroch v slovenskom aj anglickom jazyku. Pedagogick\u00ed pracovn\u00edci \u00fastavu pripravili obrazov\u00fd a textov\u00fd materi\u00e1l z aktu\u00e1lnych predn\u00e1\u0161ok pre \u0161tudentov v\u0161eobecn\u00e9ho a zubn\u00e9ho lek\u00e1rstva, ako aj general medicine a dental medicine. Elektronick\u00e1 u\u010debnica z cytol\u00f3gie, v\u0161eobecnej histol\u00f3gie tkan\u00edv a mikroskopickej anat\u00f3mie je dostupn\u00e1 na webovom s\u00eddle LF UPJ\u0160.<\/p>\n\n\n\n
Vo vedecko-v\u00fdskumnej \u010dinnosti sa \u00fastav zameriava na histologick\u00fa anal\u00fdzu morfometrick\u00fdch parametrov, histochemick\u00fa a imunohistochemick\u00fa kvantifik\u00e1ciu z\u00e1palov\u00fdch buniek, zlo\u017eiek medzibunkov\u00e9ho matrixu a pos\u00fadenie celkovej \u00fa\u010dasti apoptotickej bunkovej smrti v komplexe ischemicko-reperf\u00fazneho po\u0161kodenia tenk\u00e9ho \u010dreva po aplik\u00e1cii vybran\u00fdch natur\u00e1lnych antioxidantov in vivo na modeli laborat\u00f3rneho potkana. Na po\u0161koden\u00e9 org\u00e1ny \u2013 tenk\u00e9 \u010drevo, p\u013e\u00faca, pe\u010de\u0148 a slezina sa aplikuj\u00fa postupy a met\u00f3dy molekulovej histol\u00f3gie, ako expresia vybran\u00fdch z\u00e1palov\u00fdch a apoptotick\u00fdch markerov.<\/p>\n\n\n\n
\u00dastav rie\u0161i aj problematiku z\u00edskavania tolerancie farmakologick\u00fdm prekondicionovan\u00edm alebo postkondicionovan\u00edm pri glob\u00e1lnej isch\u00e9mii mozgu potkanov a isch\u00e9mii v mieche kr\u00e1likov v r\u00e1mci grantu VEGA. Projekt sk\u00fama mechanizmy mo\u017enej ochrany neur\u00f3nov pred ischemicko \u2013 reperf\u00faznym po\u0161koden\u00edm na imunohistochemickej a biochemickej \u00farovni.<\/p>\n\n\n\n
Novou problematikou rie\u0161enou na \u00fastave v r\u00e1mci grantu APVV a v spolupr\u00e1ci s klinick\u00fdmi pracoviskami, je sk\u00famanie pr\u00edtomnosti agreg\u00e1tov \u03b1-synukle\u00ednu v bioptickom materi\u00e1li z hrub\u00e9ho \u010dreva, ktor\u00e9 by mohli by\u0165 potenci\u00e1lnym biomarkerom Parkinsonovej choroby u\u017e v premotorickom \u0161t\u00e1diu ochorenia.<\/p>\n\n\n\n
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