{"id":126597,"date":"2025-01-15T11:08:51","date_gmt":"2025-01-15T10:08:51","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/?post_type=cpt_aktuality&#038;p=126597"},"modified":"2025-01-15T11:09:28","modified_gmt":"2025-01-15T10:09:28","slug":"experimentalna-liecba-chronickej-bolesti","status":"publish","type":"cpt_aktuality","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/actuality\/experimentalna-liecba-chronickej-bolesti\/","title":{"rendered":"Experiment\u00e1lna lie\u010dba chronickej bolesti"},"content":{"rendered":"\n<p>D\u0148a 14. janu\u00e1ra 2025 sa na Lek\u00e1rskej fakulte UPJ\u0160 v Ko\u0161iciach uskuto\u010dnil semin\u00e1r na t\u00e9mu <strong>\u201eExperimental therapies for chronic pain\u201c<\/strong>, kde predn\u00e1\u0161ala <strong>Dr. Stanislava Jergov\u00e1, Ph.D.<\/strong>, z Department of Neurological Surgery, University of Miami, Miller School of Medicine, USA.<\/p>\n\n\n\n<p>Dr. Jergov\u00e1 p\u00f4sob\u00ed na poz\u00edcii Research Assistant Professor v laborat\u00f3riu <strong>Miami Project to Cure Paralysis<\/strong>, kde sa venuje v\u00fdskumu terapi\u00ed na zmiernenie chronickej bolesti, predov\u0161etk\u00fdm v d\u00f4sledku po\u0161kodenia miechy, s vyu\u017eit\u00edm bunkovej a g\u00e9novej terapie. Po\u010das semin\u00e1ra predstavila najnov\u0161ie v\u00fdsledky v&nbsp;tejto oblasti s prepojen\u00edm na predklinick\u00e9 testovanie.<\/p>\n\n\n\n<p><strong>V\u00fdskum na University of Miami<\/strong><\/p>\n\n\n\n<p>Laborat\u00f3rium Dr. Jergovej sa zameriava na odha\u013eovanie mechanizmov chronickej neuropatickej bolesti vyvolanej poranen\u00edm miechy (SCI) a in\u00fdmi poraneniami centr\u00e1lneho nervov\u00e9ho syst\u00e9mu. Sk\u00fama mo\u017enosti vyu\u017eitia bunkovej a g\u00e9novej terapie na zmiernenie tejto bolesti. Chronick\u00e1 boles\u0165 je multifaktori\u00e1lny stav, ktor\u00fd si vy\u017eaduje zacielenie viacer\u00fdch sign\u00e1lnych dr\u00e1h s presnou lokaliz\u00e1ciou pre efekt\u00edvnu lie\u010dbu s minim\u00e1lnymi ved\u013eaj\u0161\u00edmi \u00fa\u010dinkami.<\/p>\n\n\n\n<p>Vo v\u00fdskume sa zameriavaj\u00fa na dysfunk\u010dn\u00fa inhibi\u010dn\u00fa GABAergick\u00fa signaliz\u00e1ciu a zv\u00fd\u0161en\u00fa signaliz\u00e1ciu cez glutam\u00e1tov\u00e9 NMDA receptory, ktor\u00e9 s\u00fa k\u013e\u00fa\u010dov\u00fdmi faktormi vo v\u00fdvoji chronickej bolesti. V laborat\u00f3riu bolo preuk\u00e1zan\u00e9, \u017ee rekombinantn\u00e9 GABAergick\u00e9 bunky z\u00edskan\u00e9 z potkanov dok\u00e1\u017eu \u00fa\u010dinne zmierni\u0165 chronick\u00fa boles\u0165 na zvierac\u00edch modeloch. Tieto bunky m\u00f4\u017eu by\u0165 vybaven\u00e9 g\u00e9nmi k\u00f3duj\u00facimi mal\u00e9 analgetick\u00e9 peptidy, \u010do umo\u017e\u0148uje zacielenie viacer\u00fdch dr\u00e1h bolesti.<\/p>\n\n\n\n<p>Aktu\u00e1lny v\u00fdskum vyu\u017e\u00edva rekombinantn\u00e9 GABAergick\u00e9 \u013eudsk\u00e9 pluripotentn\u00e9 kme\u0148ov\u00e9 bunky odvoden\u00e9 z ko\u017en\u00fdch alebo krvn\u00fdch buniek dospel\u00fdch jedincov, ktor\u00e9 s\u00fa geneticky upraven\u00e9 na obnovenie inhibi\u010dnej rovnov\u00e1hy v mieche a cielen\u00e9 dodanie analgetick\u00fdch l\u00e1tok.<\/p>\n\n\n\n<p>T\u00edm Dr. Jergovej sa venuje aj v\u00fdskumu exoz\u00f3mov ako potenci\u00e1lneho biomarkera, lie\u010debnej l\u00e1tky a n\u00e1stroja na dodanie rekombinantn\u00fdch analgetick\u00fdch g\u00e9nov do cie\u013eov\u00fdch buniek miechy. V\u00fdskum zah\u0155\u0148a aj regulovan\u00e9 uvo\u013e\u0148ovanie terapeutick\u00fdch l\u00e1tok z rekombinantn\u00fdch buniek prostredn\u00edctvom optogenetick\u00e9ho pr\u00edstupu. Cie\u013eom je lep\u0161ie pochopi\u0165 mechanizmy chronickej bolesti a vyvin\u00fa\u0165 nov\u00e9 lie\u010debne mo\u017enosti poskytuj\u00face pacientom bezpe\u010dn\u00fa a dlhodob\u00fa \u00fa\u013eavu od bolesti.<\/p>\n\n\n\n<p><strong>Vedecko-v\u00fdskumn\u00e1 spolupr\u00e1ca<\/strong><\/p>\n\n\n\n<p>V r\u00e1mci spolupr\u00e1ce s Neurobiologick\u00fdm \u00fastavom SAV v Ko\u0161iciach a klinick\u00fdm v\u00fdskumom na UNLP v Ko\u0161iciach je na m\u00e1j 2025 pl\u00e1novan\u00fd spolo\u010dn\u00fd semin\u00e1r na LF UPJ\u0160. S\u00fa\u010das\u0165ou spolupr\u00e1ce je aj pripravovan\u00fd spolo\u010dn\u00fd medzin\u00e1rodn\u00fd projekt, ktor\u00fd sa bude zameriava\u0165 na pokra\u010dovanie v\u00fdskumu v oblasti chronickej bolesti a jej lie\u010dby.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>D\u0148a 14. janu\u00e1ra 2025 sa na Lek\u00e1rskej fakulte UPJ\u0160 v Ko\u0161iciach uskuto\u010dnil semin\u00e1r na t\u00e9mu \u201eExperimental therapies for chronic pain\u201c, kde predn\u00e1\u0161ala Dr. Stanislava Jergov\u00e1, Ph.D., z Department of Neurological Surgery, University of Miami, Miller School of Medicine, USA. Dr. Jergov\u00e1 p\u00f4sob\u00ed na poz\u00edcii Research Assistant Professor v laborat\u00f3riu Miami Project to Cure Paralysis, kde &hellip; <a href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/actuality\/experimentalna-liecba-chronickej-bolesti\/\">\u010c\u00edta\u0165 \u010falej<\/a><\/p>\n","protected":false},"author":97,"featured_media":126604,"template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[],"tags":[],"tax_aktuality":[],"class_list":["post-126597","cpt_aktuality","type-cpt_aktuality","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":"","poradie_clanku":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Experiment\u00e1lna lie\u010dba chronickej bolesti - Lek\u00e1rska fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/actuality\/experimentalna-liecba-chronickej-bolesti\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Experiment\u00e1lna lie\u010dba chronickej bolesti - Lek\u00e1rska fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"D\u0148a 14. janu\u00e1ra 2025 sa na Lek\u00e1rskej fakulte UPJ\u0160 v Ko\u0161iciach uskuto\u010dnil semin\u00e1r na t\u00e9mu \u201eExperimental therapies for chronic pain\u201c, kde predn\u00e1\u0161ala Dr. Stanislava Jergov\u00e1, Ph.D., z Department of Neurological Surgery, University of Miami, Miller School of Medicine, USA. 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