{"id":65913,"date":"2020-04-19T15:51:55","date_gmt":"2020-04-19T15:51:55","guid":{"rendered":"https:\/\/www.upjs.sk\/lekarska-fakulta\/pracoviska\/laboratory-of-cell-interactions\/"},"modified":"2022-11-15T12:11:15","modified_gmt":"2022-11-15T11:11:15","slug":"laboratory-of-cell-interactions","status":"publish","type":"cpt_pracoviska","link":"https:\/\/www.upjs.sk\/lekarska-fakulta\/en\/pracoviska\/laboratory-of-cell-interactions\/","title":{"rendered":"Laboratory of Cell Interactions"},"content":{"rendered":"\n\n\n\n
Trieda SNP 1, 040 11 Ko\u0161ice<\/td>\n\"Slovensk\u00e1<\/a><\/td>\n<\/tr>\n
\u00a0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

The LBI research is focused on the study of cell interactions involved in the regulation of the microenvironment of tumors and wounds with the possibility of their therapeutic modulation. LCI is directly connected to the Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc. and is closely cooperating with several domestic and foreign research groups.<\/p>\n

https:\/\/www.upjs.sk\/lekarska-fakulta\/centrum-vyskumu\/medipark\/aktuality\/22466\/<\/a><\/p>\n

Domestic collaboration includes Department of Pharmacology of P.J. \u0160af\u00e1rik University \u2013 Faculty of Medicine in Ko\u0161ice and Department of Pharmacognosy and Botany of Comenius University \u2013 Faculty of Pharmacy in Bratislava. Long-term cooperation with laboratory of prof. Dr. Hans-Joachim Gabius from Ludwig-Maximilian University in Munich and laboratory of prof. MD. Karel Smetana, DrSc. from Institute of Anatomy, First Faculty of Medicine, Charles University is focused on glycobiology and cell interactions in tumors and wounds. Recently, our laboratory has also been involved in development of active and antibacterial wound dressings, especially with Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, the group of Ing. Dominik Rejman, CSc. from Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences and prof. RNDr. David Luk\u00e1\u0161, CSc. Laboratory of nanofibre and nanosurface preparation at Technical University of Liberec.<\/p>\n

\u00a0<\/p>\n

Senior researcher<\/strong>
\nPeter Gal, PhD, MBA<\/p>\n

PhD students<\/strong>
\nNikola Melegov\u00e1
\nMiriam Gurb\u00e1\u013eov\u00e1
\nLuk\u00e1\u0161 Urban<\/p>\n

\u00a0<\/p>\n

Selected publications<\/strong><\/p>\n

    \n
  1. Zajicek R, Kubok R, Petrova N, Tokarik M, Matouskova E, Gal P. Complex approach of skin repair in extensively burned child: bilayer Integra\u00ae and skin grafting facilitated by non-cultured autologous skin cells and Xe-Derma\u00ae. J Wound Care. in press<\/li>\n
  2. Michalov\u00e1 Z, \u010coma M, Ki\u010dov\u00e1 M, Gabzdilov\u00e1 J, Dedinsk\u00e1 K, Guman T, H\u00e1jikov\u00e1 M, Veselinyov\u00e1 D, Giertlova M, G\u00e1l P, \u0160ari\u0161sk\u00fd M. Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report. Anticancer Res. 2019 Jun;39(6):2805-2810.<\/li>\n
  3. F\u00e1ber L, Kov\u00e1\u010d I, Mitrengov\u00e1 P, Novotn\u00fd M, Varinsk\u00e1 L, Vasilenko T, Kello M, \u010coma M, Kuruc T, Petrov\u00e1 K, Mil\u00e1\u010dkov\u00e1 I, Kuczmannov\u00e1 A, Per\u017ee\u013eov\u00e1 V, Mi\u017e\u00e1kov\u00e1 \u0160, Dosedla E, Sabol F, Luczy J, Nagy M, Majern\u00edk J, Ko\u0161\u010do M, Mu\u010daji P, G\u00e1l P. Genistein Improves Skin Flap Viability in Rats: A Preliminary In Vivo and In Vitro Investigation. Molecules. 2018 Jul 4;23(7). pii: E1637.<\/li>\n
  4. Zivicova V, Gal P, Mifkova A, Novak S, Kaltner H, Kolar M, Strnad H, Sachova J, Hradilova M, Chovanec M, Gabius HJ, Smetana K Jr, Fik Z. Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive\/-negative Head and Neck Squamous Cell Carcinoma. Anticancer Res. 2018 Mar;38(3):1279-1290.<\/li>\n
  5. G\u00e1l P, Varinsk\u00e1 L, F\u00e1ber L, Nov\u00e1k \u0160, Szabo P, Mitrengov\u00e1 P, Mirossay A, Mu\u010daji P, Smetana K. How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair. Molecules. 2017 Oct 26;22(11). pii: E1818.<\/li>\n
  6. Per\u017ee\u013eov\u00e1 V, Sabol F, Vasilenko T, Novotn\u00fd M, Kov\u00e1\u010d I, Slez\u00e1k M, \u010eurk\u00e1\u010d J, Holl\u00fd M, Pil\u00e1tov\u00e1 M, Szabo P, Varinsk\u00e1 L, \u010criepokov\u00e1 Z, Ku\u010dera T, Kaltner H, Andr\u00e9 S, Gabius HJ, Mu\u010daji P, Smetana K Jr, G\u00e1l P. Pharmacological activation of estrogen receptors-\u03b1 and -\u03b2 differentially modulates keratinocyte differentiation with functional impact on wound healing. Int J Mol Med. 2016 Jan;37(1):21-8.<\/li>\n
  7. Kov\u00e1\u010d I, \u010eurk\u00e1\u010d J, Holl\u00fd M, Jakub\u010dov\u00e1 K, Per\u017ee\u013eov\u00e1 V, Mu\u010daji P, \u0160vajdlenka E, Sabol F, Leg\u00e1th J, Bel\u00e1k J, Smetana K Jr, G\u00e1l P. Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds. J Pharm Pharmacol. 2015 Jan;67(1):117-25.<\/li>\n
  8. Valach J, F\u00edk Z, Strnad H, Chovanec M, Plz\u00e1k J, Cada Z, Szabo P, S\u00e1chov\u00e1 J, Hroudov\u00e1 M, Urbanov\u00e1 M, Steffl M, Pa\u010des J, Maz\u00e1nek J, Vl\u010dek C, Betka J, Kaltner H, Andr\u00e9 S, Gabius HJ, Kodet R, Smetana K Jr, G\u00e1l P, Kol\u00e1\u0159 M. Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor prognosis factors. Int J Cancer. 2012 Dec 1;131(11):2499-508.<\/li>\n
  9. Novotn\u00fd M, Vasilenko T, Varinsk\u00e1 L, Smetana K Jr, Szabo P, Sari\u0161sk\u00fd M, Dvo\u0159\u00e1nkov\u00e1 B, Moj\u017ei\u0161 J, Bobrov N, Toporcerov\u00e1 S, Sabol F, Matthews BJ, G\u00e1l P. ER-\u03b1 agonist induces conversion of fibroblasts into myofibroblasts, while ER-\u03b2 agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised rats. Exp Dermatol. 2011 Sep;20(9):703-8.<\/li>\n
  10. Dvo\u0159\u00e1nkov\u00e1 B, Szabo P, Lacina L, Gal P, Uhrova J, Zima T, Kaltner H, Andr\u00e9 S, Gabius HJ, Sykova E, Smetana K Jr. Human galectins induce conversion of dermal fibroblasts into myofibroblasts and production of extracellular matrix: potential application in tissue engineering and wound repair. Cells Tissues Organs. 2011;194(6):469-80.<\/li>\n<\/ol>\n

    Supplementary material to our publications<\/strong><\/a><\/p>\n","protected":false},"author":1,"featured_media":29726,"parent":0,"menu_order":11,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}"},"class_list":["post-65913","cpt_pracoviska","type-cpt_pracoviska","status-publish","has-post-thumbnail","hentry"],"acf":{"acf_link_na_externy_obsah":""},"yoast_head":"\nLaboratory of Cell Interactions - Lek\u00e1rska fakulta | UPJ\u0160<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.upjs.sk\/lekarska-fakulta\/en\/pracoviska\/laboratory-of-cell-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Laboratory of Cell Interactions - Lek\u00e1rska fakulta | UPJ\u0160\" \/>\n<meta property=\"og:description\" content=\"Trieda SNP 1, 040 11 Ko\u0161ice \u00a0 The LBI research is focused on the study of cell interactions involved in the regulation of the microenvironment of tumors and wounds with the possibility of their therapeutic modulation. 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