Transcriptome and metabolome of bioactive compounds with anticancer activity in the genus Hypericum (guarantee prof. Čellárová)
Research within this topic is concentrated at identification and validation of candidate genes of biosynthesis of bioactive compounds in the genus Hypericum, temporal-spatial regulation of their biosynthesis, identification of endophytic microorganisms from the representatives of the genus Hypericum and characterisation of their biosynthetic potential and at feasibility of targeted enhancement of production of bioactive compounds by biotechnological alternative.
Signalome of bioactive compounds with anticancer activity (guarantee prof. Fedoročko)
This part of research is focused at elucidation of intra- and extracellular signalization during photodynamic cancer therapy because understanding of the processes associated with the cell death, angiogenesis, role of intercellular interactions and the effect of microenvironment, autorenewal and differentiation of cancer stem cells, as well as mechanisms of multiple drug resistance may provide, by the knowledge on regulation of the cell signalling pathways, new possibilities for rational therapy and new drugs design.
Scientometry
The team personalities published together more than 200 original papers which appeared in peer reviewed journals. The number of citations in WOS and Scopus exceeded 4000.
The most significant papers published in the years 2015-2016
Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging / Souvik Kusari … [et al.].
In: Analytical and Bioanalytical Chemistry. – ISSN 1618-2642. – Vol. 407, no. 16 (2015), s. 4779-4791.
[KUSARI, Souvik – SEZGIN, Selahaddin – NIGUTOVÁ, Katarína – ČELLÁROVÁ, Eva – SPITELLER, Michael]
The role of ABA in the freezing injury avoidance in two Hypericum species differing in frost tolerance and potential to synthesize hypericins / Katarína Bruňáková … [et al.].
In: Plant Cell Tissue and Organ Culture. – ISSN 0167-6857. – Vol. 122, no. 1 (2015), s. 45-56.
[BRUŇÁKOVÁ, Katarína – PETIJOVÁ, Linda – ZÁMEČNÍK, Jiří – TUREČKOVÁ, Veronika – ČELLÁROVÁ, Eva]
Xanthones from roots, hairy roots and cell suspension cultures of selected Hypericum species and their antifungal activity against Candida albicans / Daniela Zubrická … [et al.].
In: Plant Cell Reports. – ISSN 0721-7714. – Vol. 34, no. 11 (2015), s. 1953-1962.
[ZUBRICKÁ, Daniela – MIŠIANIKOVÁ, Anna – HENZELYOVÁ, Jana – VALLETTA, Alessio – DE ANGELIS, Giulia – DIODATA D´AURIA, Felicia – SIMONETTI, Giovanna – PASQUA, Gabriella – ČELLÁROVÁ, Eva]
Conservation Strategies in the Genus Hypericum via Cryogenic Treatment / Katarína Bruňáková, Eva Čellárová.
In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 558.
[BRUŇÁKOVÁ, Katarína – ČELLÁROVÁ, Eva]
Effect of cryoprotectant solution and of cooling rate on crystallization temperature in cryopreserved Hypericum perforatum cell suspension cultures / Anna Mišianiková … [et al.].
In: Cryoletters. – ISSN 0143-2044. – Vol. 37, no. 3 (2016), s. 173-187.
[MIŠIANIKOVÁ, Anna – ZUBRICKÁ, Daniela – PETIJOVÁ, Linda – BRUŇÁKOVÁ, Katarína – ČELLÁROVÁ, Eva]
Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging / Andrea Kucharíková … [et al.].
In: Physiologia Plantarum. – ISSN 0031-9317. – Vol. 157, no. 1 (2016), s. 2-12.
[KUCHARÍKOVÁ, Andrea – KIMÁKOVÁ, Katarína – JANFLET, Christian – ČELLÁROVÁ, Eva]
Occurrence and distribution of phytochemicals in the leaves of 17 in vitro cultured Hypericum spp. adapted to outdoor conditions / Andrea Kucharíková … [et al.]. In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 1616.
[KUCHARÍKOVÁ, Andrea – KUSARI, Souvik – SEZGIN, Selahaddin – SPITELLER, Michael – ČELLÁROVÁ, Eva]
Differentially Expressed Genes in Hypericin-Containing Hypericum perforatum Leaf Tissues as Revealed by De Novo Assembly of RNA-Seq /Miroslav Soták … [et al.]. In Plant Molecular Biology Reporter. – ISSN: 0735-9640 – Vol. 34 (2016), number 5, s. 1027-1041
[SOTÁK, Miroslav – CZERANKOVÁ, Odeta – KLEIN, Daniel – NIGUTOVÁ, Katarína – ALTSCHMIED, Lothar, LI, Ling – JOSE, Adarsh – WURTELE, Eva Syrkin – ČELLÁROVÁ, Eva]
Comparative transcriptome reconstruction of four Hypericum species focused on hypericin biosynthesis / Miroslav Soták … [et al.]. In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 1039
[SOTÁK, Miroslav – CZERANKOVÁ, Odeta – KLEIN, Daniel – JURČACKOVÁ, Zuzana – LI, Ling – ČELLÁROVÁ, Eva]
Shoot tip meristem cryopreservation of Hypericum Species / Katarína Bruňáková, Eva Čellárová. In: Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants. – Nev York : Springer Science+Business Media, 2016. – ISBN 9781493933303. – S. 31-46
DNA-protective activities of hyperforin and aristoforin / A. Ševčovičová … [et al.].
In: Toxicology in Vitro. – ISSN 0887-2333. – Vol. 29, no. 3 (2015), s. 631-637.
[ŠEVČOVIČOVÁ, Andrea – ŠEMELÁKOVÁ, Martina – PLŠÍKOVÁ, Jana – LODERER, Dušan – IMREOVÁ, Petronela – GÁLOVÁ, Eliška – KOŽURKOVÁ, Mária – MIADOKOVÁ, Eva – FEDOROČKO, Peter]
Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells / Lucia Hiľovská … [et al.].
In: International Journal of Oncology. – ISSN 1019-6439. – Vol. 47, no. 4 (2015), s. 1572-1584.
[HIĽOVSKÁ, Lucia – JENDŽELOVSKÝ, Rastislav – JENDŽELOVSKÁ, Zuzana – KOVAĽ, Ján – FEDOROČKO, Peter]
Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status / Barbora Kuchárová … [et al.].
In: Photodiagnosis and Photodynamic Therapy. – ISSN 1572-1000. – Vol. 12, no. 3 (2015), s. 490-503.
[KUCHÁROVÁ, Barbora – MIKEŠ, Jaromír – JENDŽELOVSKÝ, Rastislav – VARGOVÁ, Jana – MIKEŠOVÁ, Lucia – JENDŽELOVSKÁ, Zuzana – KOVAĽ, Ján – FEDOROČKO, Peter]
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells / M. Šemeláková, R. Jendželovský, P. Fedoročko.
In: Biomedicine & Pharmacotherapy. – ISSN 0753-3322. – Vol. 81 (2016), s. 38-47.
[ŠEMELÁKOVÁ, Martina – JENDŽELOVSKÝ, Rastislav – FEDOROČKO, Peter]
Hypericin in the light and in the dark: two sides of the same coin / Zuzana Jendželovská … [et al.].
In: Frontiers in Plant Science. – ISSN 1664-462X. – Vol. 7 (2016), art.no. 560.
[JENDŽELOVSKÁ, Zuzana – JENDŽELOVSKÝ, Rastislav – KUCHÁROVÁ, Barbora – FEDOROČKO, Peter]
Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin / Rastislav Jendželovský … [et al.].
In: Toxicology Letters. – ISSN 0378-4274. – Vol. 243 (2016), s. 56-66.
[JENDŽELOVSKÝ, Rastislav – JENDŽELOVSKÁ, Zuzana – HIĽOVSKÁ, Lucia – KOVAĽ, Ján – MIKEŠ, Jaromír – FEDOROČKO, Peter]
YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy / Katarína Gyuraszova … [et al.].
In: Photochemical & Photobiological Sciences. – ISSN 1474-905X. – Vol. 15, no. 6 (2016), s. 812-821.
[GYURÁSZOVÁ, Katarína – MIKEŠ, Jaromír – HALABURKOVÁ, Andrea – JENDŽELOVSKÝ, Rastislav – FEDOROČKO, Peter]
