Laboratory of Cell Interactions

Trieda SNP 1, 040 11 Košice

The LBI research is focused on the study of cell interactions involved in the regulation of the microenvironment of tumors and wounds with the possibility of their therapeutic modulation. LCI is directly connected to the Department of Biomedical Research, East-Slovak Institute of Cardiovascular Diseases, Inc. and is closely cooperating with several domestic and foreign research groups.

https://www.upjs.sk/lekarska-fakulta/centrum-vyskumu/medipark/aktuality/22466/

Domestic collaboration includes Department of Pharmacology of P.J. Šafárik University – Faculty of Medicine in Košice and Department of Pharmacognosy and Botany of Comenius University – Faculty of Pharmacy in Bratislava. Long-term cooperation with laboratory of prof. Dr. Hans-Joachim Gabius from Ludwig-Maximilian University in Munich and laboratory of prof. MD. Karel Smetana, DrSc. from Institute of Anatomy, First Faculty of Medicine, Charles University is focused on glycobiology and cell interactions in tumors and wounds. Recently, our laboratory has also been involved in development of active and antibacterial wound dressings, especially with Prague Burn Centre, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, the group of Ing. Dominik Rejman, CSc. from Institute of Organic Chemistry and Biochemistry of Czech Academy of Sciences and prof. RNDr. David Lukáš, CSc. Laboratory of nanofibre and nanosurface preparation at Technical University of Liberec.

Senior researcher
Peter Gal, PhD, MBA

PhD students
Nikola Melegová
Miriam Gurbáľová
Lukáš Urban

Selected publications

1. Zajicek R, Kubok R, Petrova N, Tokarik M, Matouskova E, Gal P. Complex approach of skin repair in extensively burned child: bilayer Integra® and skin grafting facilitated by non-cultured autologous skin cells and Xe-Derma®. J Wound Care. in press
2. Michalová Z, Čoma M, Kičová M, Gabzdilová J, Dedinská K, Guman T, Hájiková M, Veselinyová D, Giertlova M, Gál P, Šarišský M. Overexpression of Galectin-3 in Chronic Lymphocytic Leukemia Is Associated With 17p Deletion: A Short Report. Anticancer Res. 2019 Jun;39(6):2805-2810.
3. Fáber L, Kováč I, Mitrengová P, Novotný M, Varinská L, Vasilenko T, Kello M, Čoma M, Kuruc T, Petrová K, Miláčková I, Kuczmannová A, Peržeľová V, Mižáková Š, Dosedla E, Sabol F, Luczy J, Nagy M, Majerník J, Koščo M, Mučaji P, Gál P. Genistein Improves Skin Flap Viability in Rats: A Preliminary In Vivo and In Vitro Investigation. Molecules. 2018 Jul 4;23(7). pii: E1637.
4. Zivicova V, Gal P, Mifkova A, Novak S, Kaltner H, Kolar M, Strnad H, Sachova J, Hradilova M, Chovanec M, Gabius HJ, Smetana K Jr, Fik Z. Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma. Anticancer Res. 2018 Mar;38(3):1279-1290.
5. Gál P, Varinská L, Fáber L, Novák Š, Szabo P, Mitrengová P, Mirossay A, Mučaji P, Smetana K. How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair. Molecules. 2017 Oct 26;22(11). pii: E1818.
6. Peržeľová V, Sabol F, Vasilenko T, Novotný M, Kováč I, Slezák M, Ďurkáč J, Hollý M, Pilátová M, Szabo P, Varinská L, Čriepoková Z, Kučera T, Kaltner H, André S, Gabius HJ, Mučaji P, Smetana K Jr, Gál P. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing. Int J Mol Med. 2016 Jan;37(1):21-8.
7. Kováč I, Ďurkáč J, Hollý M, Jakubčová K, Peržeľová V, Mučaji P, Švajdlenka E, Sabol F, Legáth J, Belák J, Smetana K Jr, Gál P. Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds. J Pharm Pharmacol. 2015 Jan;67(1):117-25.
8. Valach J, Fík Z, Strnad H, Chovanec M, Plzák J, Cada Z, Szabo P, Sáchová J, Hroudová M, Urbanová M, Steffl M, Pačes J, Mazánek J, Vlček C, Betka J, Kaltner H, André S, Gabius HJ, Kodet R, Smetana K Jr, Gál P, Kolář M. Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor prognosis factors. Int J Cancer. 2012 Dec 1;131(11):2499-508.
9. Novotný M, Vasilenko T, Varinská L, Smetana K Jr, Szabo P, Sarišský M, Dvořánková B, Mojžiš J, Bobrov N, Toporcerová S, Sabol F, Matthews BJ, Gál P. ER-α agonist induces conversion of fibroblasts into myofibroblasts, while ER-β agonist increases ECM production and wound tensile strength of healing skin wounds in ovariectomised rats. Exp Dermatol. 2011 Sep;20(9):703-8.
10. Dvořánková B, Szabo P, Lacina L, Gal P, Uhrova J, Zima T, Kaltner H, André S, Gabius HJ, Sykova E, Smetana K Jr. Human galectins induce conversion of dermal fibroblasts into myofibroblasts and production of extracellular matrix: potential application in tissue engineering and wound repair. Cells Tissues Organs. 2011;194(6):469-80.

Supplementary material to our publications

Prílohy

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